Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

E Smirnova, MD Muthiah, N Narayan, MS Siddiqui… - Hepatology, 2022 - journals.lww.com
Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

[PDF][PDF] Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis

C Harrington, S Krishnan, CL Mack, P Cravedi… - …, 2022 - Wiley Online Library
Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

[HTML][HTML] 2016 comprehensive update of the Banff working group on liver allograft pathology: introduction of antibody-mediated rejection

AJ Demetris, C Bellamy, SG Hübscher, J O'leary… - American Journal of …, 2016 - Elsevier
The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature
evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France …

[PDF][PDF] Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

C Benítez, MC Londoño, R Miquel, TM Manzia… - …, 2013 - Wiley Online Library
Lifelong immunosuppression increases morbidity and mortality in liver transplantation.
Discontinuation of immunosuppressive drugs could lessen this burden, but the safety …

Understanding, predicting and achieving liver transplant tolerance: from bench to bedside

AW Thomson, J Vionnet… - Nature Reviews …, 2020 - nature.com
In the past 40 years, liver transplantation has evolved from a high-risk procedure to one that
offers high success rates for reversal of liver dysfunction and excellent patient and graft …

Disappearance of T cell-mediated rejection despite continued antibody-mediated rejection in late kidney transplant recipients

PF Halloran, J Chang, K Famulski… - Journal of the …, 2015 - journals.lww.com
The prevalent renal transplant population presents an opportunity to observe the adaptive
changes in the alloimmune response over time, but such studies have been limited by …

Efficacy and safety of immunosuppression withdrawal in pediatric liver transplant recipients: moving toward personalized management

S Feng, JC Bucuvalas, GV Mazariegos, JC Magee… - …, 2021 - Wiley Online Library
Background and Aims Tolerance is transplantation's holy grail, as it denotes allograft health
without immunosuppression and its toxicities. Our aim was to determine, among stable long …

[HTML][HTML] From immunosuppression to tolerance

DH Adams, A Sanchez-Fueyo, D Samuel - Journal of hepatology, 2015 - Elsevier
The past three decades have seen liver transplantation becoming a major therapeutic
approach in the management of end-stage liver diseases. This is due to the dramatic …

[HTML][HTML] Liver transplantation: fifty years of experience

ATW Song, VI Avelino-Silva, RAA Pecora… - World Journal of …, 2014 - ncbi.nlm.nih.gov
Since 1963, when the first human liver transplantation (LT) was performed by Thomas Starzl,
the world has witnessed 50 years of development in surgical techniques …

[HTML][HTML] Donor-derived cell-free DNA levels predict graft injury in liver transplant recipients

J Levitsky, M Kandpal, K Guo, S Kleiboeker… - American Journal of …, 2022 - Elsevier
Donor-derived cell-free DNA (dd-cfDNA) has been evaluated as a rejection marker in organ
transplantation. This study sought to assess the utility of dd-cfDNA to diagnose graft injury in …