The gut microbiome as a modulator of healthy ageing

TS Ghosh, F Shanahan, PW O'Toole - … Reviews Gastroenterology & …, 2022 - nature.com
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

The role of goblet cells and mucus in intestinal homeostasis

JK Gustafsson, MEV Johansson - Nature reviews Gastroenterology & …, 2022 - nature.com
The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

Gut barrier disruption and chronic disease

J Martel, SH Chang, YF Ko, TL Hwang… - Trends in Endocrinology …, 2022 - cell.com
The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week

L Liberale, L Badimon, F Montecucco… - Journal of the American …, 2022 - jacc.org
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …

Brain–gut–microbiome interactions in obesity and food addiction

A Gupta, V Osadchiy, EA Mayer - Nature Reviews Gastroenterology & …, 2020 - nature.com
Normal eating behaviour is coordinated by the tightly regulated balance between intestinal
and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a …

Gut microbiota, muscle mass and function in aging: a focus on physical frailty and sarcopenia

A Ticinesi, A Nouvenne, N Cerundolo, P Catania… - Nutrients, 2019 - mdpi.com
Human gut microbiota is able to influence the host physiology by regulating multiple
processes, including nutrient absorption, inflammation, oxidative stress, immune function …

[HTML][HTML] Gut microbiota remodeling improves natural aging-related disorders through Akkermansia muciniphila and its derived acetic acid

J Ma, Z Liu, X Gao, Y Bao, Y Hong, X He, W Zhu… - Pharmacological …, 2023 - Elsevier
Accumulating evidence indicates gut microbiota contributes to aging-related disorders.
However, the exact mechanism underlying gut dysbiosis-related pathophysiological …

Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan

J Johansen, K Atarashi, Y Arai, N Hirose… - Nature …, 2023 - nature.com
Distinct gut microbiome ecology may be implicated in the prevention of aging-related
diseases as it influences systemic immune function and resistance to infections. Yet, the viral …

The microbiome as a modifier of neurodegenerative disease risk

P Fang, SA Kazmi, KG Jameson, EY Hsiao - Cell host & microbe, 2020 - cell.com
The gut microbiome is increasingly implicated in modifying susceptibility to and progression
of neurodegenerative diseases (NDs). In this review, we discuss roles for the microbiome in …

Oral–gut microbiome axis in gastrointestinal disease and cancer

SY Park, BO Hwang, M Lim, SH Ok, SK Lee, KS Chun… - Cancers, 2021 - mdpi.com
Simple Summary Microbiota dysbiosis is correlated with numerous diseases in the human
body. To date, the research on the microbiome-associated diseases been focused on an …