[HTML][HTML] The role of IL-6 in cancer cell invasiveness and metastasis—overview and therapeutic opportunities

M Rašková, L Lacina, Z Kejík, A Venhauerová… - Cells, 2022 - mdpi.com
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

[HTML][HTML] The exercise IL-6 enigma in cancer

ST Orange, J Leslie, M Ross, DA Mann… - Trends in Endocrinology …, 2023 - cell.com
Abstract Interleukin (IL)-6 elicits both anticancer and procancer effects depending on the
context, which we have termed the 'exercise IL-6 enigma'. IL-6 is released from skeletal …

[HTML][HTML] Tumor evolution and chemoresistance in ovarian cancer

S Kim, Y Han, SI Kim, HS Kim, SJ Kim… - NPJ precision oncology, 2018 - nature.com
Abstract Development of novel strategies to overcome chemoresistance is central goal in
ovarian cancer research. Natural history of the cancer development and progression is …

[HTML][HTML] The role of inflammation and inflammatory mediators in the development, progression, metastasis, and chemoresistance of epithelial ovarian cancer

SS Savant, S Sriramkumar, HM O'Hagan - Cancers, 2018 - mdpi.com
Inflammation plays a role in the initiation and development of many types of cancers,
including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a …

[HTML][HTML] Ovarian cancer stem cells: still an elusive entity?

M Lupia, U Cavallaro - Molecular cancer, 2017 - Springer
The cancer stem cell (CSC) model proposes that tumor development and progression are
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …

[HTML][HTML] Presence and role of stem cells in ovarian cancer

NK Suster, I Virant-Klun - World journal of stem cells, 2019 - ncbi.nlm.nih.gov
Ovarian cancer is the deadliest gynecological malignancy. It is typically diagnosed at
advanced stages of the disease, with metastatic sites disseminated widely within the …

Serum IL-6 and IL-8 correlate with prognostic factors in ovarian cancer

MMM Sanguinete, PHD Oliveira… - Immunological …, 2017 - Taylor & Francis
The aim of the study was to correlate serum levels of IL-2, IL-5, IL-6, IL-8, IL-10, and TNF-α
with clinical, laboratory, and pathological prognostic factors in patients with primary ovarian …

[HTML][HTML] The transcoelomic ecosystem and epithelial ovarian cancer dissemination

SJ Ritch, CM Telleria - Frontiers in Endocrinology, 2022 - frontiersin.org
Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is
normally diagnosed at late stages, at which point metastasis has already occurred …

[HTML][HTML] Resveratrol as a tumor-suppressive nutraceutical modulating tumor microenvironment and malignant behaviors of cancer

Y Han, HA Jo, JH Cho, DN Dhanasekaran… - International journal of …, 2019 - mdpi.com
Tumor-suppressive effects of resveratrol have been shown in various types of cancer.
However, regulation of tumor microenvironment by resveratrol is still unclear. Recent …

[HTML][HTML] Activation of STAT3 and STAT5 signaling in epithelial ovarian cancer progression: mechanism and therapeutic opportunity

CJ Wu, V Sundararajan, BC Sheu, RYJ Huang, LH Wei - Cancers, 2019 - mdpi.com
Epithelial ovarian cancer (EOC) is the most lethal of all gynecologic malignancies. Despite
advances in surgical and chemotherapeutic options, most patients with advanced EOC have …