The retina has long been regarded as 'an approachable part of the brain'for investigating
neurosensory processes. Cell biologists are now capitalizing on the accessibility of the …

PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Purpose To review current literature on the renin-angiotensin system (RAS)-mediated
pathogenic mechanisms and therapeutic targets in ocular diseases. Methods A …

The renin-angiotensin system (RAS), that is known for its role in the regulation of blood
pressure as well as in fluid and electrolyte homeostasis, comprises dozens of angiotensin …

The renin–angiotensin system (RAS) is usually associated with its systemic action on
cardiovascular homoeostasis. However, recent studies suggest that at a local tissue level …

purpose. To quantify and evaluate the distribution of angiotensin II (Ang II) and its receptors
in the human retina. methods. Donor eyes were obtained within 12 hours postmortem and …

It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …

In 1989, the development of specific angiotensin receptor antagonists which distinguish
between two angiotensin receptor subtypes (AT1 and AT2) led to a breakthrough in …

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …

Angiogenesis is the formation of new blood vessels from pre-existing vasculature.
Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we …