Staphylococcal biofilms
M Otto - Microbiology spectrum, 2018 - Am Soc Microbiol
Staphylococci, with the leading species Staphylococcus aureus and Staphylococcus
epidermidis, are the most frequent causes of infections on indwelling medical devices. The …
epidermidis, are the most frequent causes of infections on indwelling medical devices. The …
Making the case for disordered proteins and biomolecular condensates in bacteria
Intrinsically disordered proteins/regions (IDPs/IDRs) contribute to a diverse array of
molecular functions in eukaryotic systems. There is also growing recognition that …
molecular functions in eukaryotic systems. There is also growing recognition that …
Deep learning in prediction of intrinsic disorder in proteins
Intrinsic disorder prediction is an active area that has developed over 100 predictors. We
identify and investigate a recent trend towards the development of deep neural network …
identify and investigate a recent trend towards the development of deep neural network …
Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains
D Santorelli, L Marcocci, V Pennacchietti… - Journal of Biological …, 2023 - ASBMB
Although cooperativity is a well-established and general property of folding, our current
understanding of this feature in multidomain folding is still relatively limited. In fact, there are …
understanding of this feature in multidomain folding is still relatively limited. In fact, there are …
[HTML][HTML] Dissecting the functional contributions of the intrinsically disordered C-terminal tail of Bacillus subtilis FtsZ
FtsZ is a bacterial GTPase that is central to the spatial and temporal control of cell division. It
is a filament-forming enzyme that encompasses a well-folded core domain and a disordered …
is a filament-forming enzyme that encompasses a well-folded core domain and a disordered …
Staphylococcal Periscope proteins Aap, SasG, and Pls project noncanonical legume-like lectin adhesin domains from the bacterial surface
LC Clark, KE Atkin, F Whelan, AS Brentnall… - Journal of Biological …, 2023 - ASBMB
Staphylococcus aureus and Staphylococcus epidermidis are frequently associated with
medical device infections that involve establishment of a bacterial biofilm on the device …
medical device infections that involve establishment of a bacterial biofilm on the device …
Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate
Although more than 75% of the proteome is composed of multidomain proteins, current
knowledge of protein folding is based primarily on studies of isolated domains. In this work …
knowledge of protein folding is based primarily on studies of isolated domains. In this work …
Self-referential encoding on modules of anticodon pairs—roots of the biological flow system
R Cardoso Guimarães - Life, 2017 - mdpi.com
The proposal that the genetic code was formed on the basis of (proto) tRNA Dimer-Directed
Protein Synthesis is reviewed and updated. The tRNAs paired through the anticodon loops …
Protein Synthesis is reviewed and updated. The tRNAs paired through the anticodon loops …
On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains
F Malagrinò, V Pennacchietti, D Santorelli, L Pagano… - Biomolecules, 2022 - mdpi.com
The vast majority of our current knowledge about the biochemical and biophysical properties
of proteins derives from in vitro studies conducted on isolated globular domains. However, a …
of proteins derives from in vitro studies conducted on isolated globular domains. However, a …
Mechanism of CcdA-mediated rejuvenation of DNA Gyrase
Most biological processes involve formation of transient complexes where binding of a
ligand allosterically modulates function. The ccd toxin-antitoxin system is involved in plasmid …
ligand allosterically modulates function. The ccd toxin-antitoxin system is involved in plasmid …