Clinical microbiology laboratories worldwide have historically relied on phenotypic methods
(ie, culture and biochemical tests) for detection, identification and characterization of …

Oral Diseases (2010) 16, 136–145 Objective: The oral cavity forms an indispensable part of
the human microbiome, for its unique and diverse microflora distributed within various …

Clinical diagnostics of chronic polymicrobial infections, such as those found in chronic
wounds, represent a diagnostic challenge for both culture and molecular methods. In the …

Diagnosis of infectious diseases suffers from long turnaround times for gold standard culture-
based identification of bacterial pathogens, therefore impeding timely specific antimicrobial …

Rapid diagnosis plays a vital role in daily life and is effective in reducing treatment costs and
increasing curability, especially in remote areas with limited availability of resources. Among …

Multiple antibiotic resistant pathogens represent a major clinical challenge in both human
and veterinary context. It is now well-understood that the genes that encode resistance are …

Polymerase chain reaction is an approach to make numerous copies of specific DNA. PCR
has been applied for the investigation of infectious sicknesses caused by viral, protozoan …

Multiplexed DNA target detection is of great significance in many fields including clinical
diagnostics, environmental monitoring, biothreat detection and forensics. Although the …

Microarrays provide a powerful analytical tool for the simultaneous detection of multiple
analytes in a single experiment. The specific affinity reaction of nucleic acids (hybridization) …

Molecular detection of microorganisms requires microbial cell disruption to release nucleic
acids. Sensitive detection of thick-walled microorganisms such as Bacillus spores and …