Role of molecular markers in thyroid nodule management: then and now

YE Nikiforov - Endocrine Practice, 2017 - Elsevier
Objective: To describe the evolution and clinical utility of molecular testing for thyroid
nodules and cancer achieved over the last 2 decades. Methods: Scientific reports on thyroid …

[HTML][HTML] Significance of RAS mutations in thyroid benign nodules and non-medullary thyroid cancer

V Marotta, M Bifulco, M Vitale - Cancers, 2021 - mdpi.com
Simple Summary Only about 4% of thyroid nodules are carcinomas and require surgery.
Fine-needle aspiration cytology is the most accurate tool to distinguish benign from …

The American Association of Endocrine Surgeons guidelines for the definitive surgical management of thyroid disease in adults

KN Patel, L Yip, CC Lubitz, EG Grubbs, BS Miller… - Annals of …, 2020 - journals.lww.com
Objective: To develop evidence-based recommendations for safe, effective, and appropriate
thyroidectomy. Background: Surgical management of thyroid disease has evolved …

Effectiveness of molecular testing techniques for diagnosis of indeterminate thyroid nodules: a randomized clinical trial

MJ Livhits, CY Zhu, EJ Kuo, DT Nguyen, J Kim… - JAMA …, 2021 - jamanetwork.com
Importance Approximately 20% of thyroid nodules display indeterminate cytology. Molecular
testing can refine the risk of malignancy and reduce the need for diagnostic …

[HTML][HTML] NTRK and RET fusion–directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake

YA Lee, H Lee, SW Im, YS Song, DY Oh… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Molecular characterization in pediatric papillary thyroid cancer (PTC),
distinct from adult PTC, is important for developing molecularly targeted therapies for …

[HTML][HTML] Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer

SK Yoo, YS Song, EK Lee, J Hwang, HH Kim… - Nature …, 2019 - nature.com
Anaplastic thyroid cancer (ATC) and advanced differentiated thyroid cancers (DTCs) show
fatal outcomes, unlike DTCs. Here, we demonstrate mutational landscape of 27 ATCs and …

Mortality risk stratification by combining BRAF V600E and TERT promoter mutations in papillary thyroid cancer: genetic duet of BRAF and TERT promoter mutations in …

R Liu, J Bishop, G Zhu, T Zhang, PW Ladenson… - JAMA …, 2017 - jamanetwork.com
Importance BRAF V600E andTERTpromoter mutations can coexist in papillary thyroid
cancer (PTC). This genetic duet was indicated to be involved in the aggressiveness of PTC …

Multiplatform molecular test performance in indeterminate thyroid nodules

MA Lupo, AE Walts, JW Sistrunk… - Diagnostic …, 2020 - Wiley Online Library
Background Approximately 25% of thyroid nodule fine‐needle aspirates (FNAs) have
cytology that is indeterminate for malignant disease. Accurate risk stratification of these …

[HTML][HTML] Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer

R Liu, T Zhang, G Zhu, M Xing - Nature communications, 2018 - nature.com
The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are
widely found to be a robust genetic background promoting human cancer aggressiveness …

Molecular profiling of 50 734 Bethesda III-VI thyroid nodules by ThyroSeq v3: implications for personalized management

S Chiosea, SP Hodak, L Yip, D Abraham… - The Journal of …, 2023 - academic.oup.com
Context Comprehensive genomic analysis of thyroid nodules for multiple classes of
molecular alterations detected in a large series of fine needle aspiration (FNA) samples has …