Guidelines and definitions for research on epithelial–mesenchymal transition
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …
[HTML][HTML] TGF-β in developmental and fibrogenic EMTs
JH Lee, J Massagué - Seminars in cancer biology, 2022 - Elsevier
TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs)
during development and wound healing and in disease conditions such as fibrosis and …
during development and wound healing and in disease conditions such as fibrosis and …
Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
WNT–β-catenin signalling—a versatile player in kidney injury and repair
SJ Schunk, J Floege, D Fliser, T Speer - Nature Reviews Nephrology, 2021 - nature.com
The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …
particular importance for morphogenesis and cell organization during embryogenesis. The …
Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer
MS Brown, B Abdollahi, OM Wilkins, H Lu… - Science …, 2022 - science.org
The epithelial-to-mesenchymal transition (EMT) is frequently co-opted by cancer cells to
enhance migratory and invasive cell traits. It is a key contributor to heterogeneity …
enhance migratory and invasive cell traits. It is a key contributor to heterogeneity …
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
A Dongre, RA Weinberg - Nature reviews Molecular cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …
The epithelial–mesenchymal plasticity landscape: Principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1
Epithelial-to-mesenchymal transitions (EMTs) are phenotypic plasticity processes that confer
migratory and invasive properties to epithelial cells during development, wound-healing …
migratory and invasive properties to epithelial cells during development, wound-healing …
Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review
Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …
undergoes a series of molecular events that lead to a change in phenotype toward a …
Emerging role of tumor cell plasticity in modifying therapeutic response
Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …
have proposed that acquisition of resistance may result from genetic mutations. However …