Exome and targeted sequencing have revolutionized clinical diagnosis. This has been
particularly striking in epilepsy and neurodevelopmental disorders, for which new genes or …

The purpose of this review is to bridge the gap between earlier literature on striatal
cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the …

Sleep quality declines with age; however, the underlying mechanisms remain elusive. We
found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation …

Objective Pathogenic variants of KCNQ 2, which encode a potassium channel subunit,
cause either benign (familial) neonatal epilepsy—B (F) NE)—or KCNQ 2 encephalopathy …

Among the five KCNQ channels, also known as the K v 7 voltage-gated potassium (K v)
channels, KCNQ2–KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2–KCNQ5 …

Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells
(ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A …

We used stimulated emission depletion (STED) superresolution microscopy to analyze the
nanoscale organization of 12 glial and axonal proteins at the nodes of Ranvier of teased …

KCNQ5 is a highly conserved gene encoding an important channel for neuronal function; it
is widely expressed in the brain and generates M-type current. Exome sequencing identified …

The activity‐dependent fusion, retrieval and recycling of synaptic vesicles is essential for the
maintenance of neurotransmission. Until relatively recently it was believed that most …

In this review, we summarize studies investigating the types and distribution of voltage-and
calcium-gated ion channels in the different classes of retinal neurons: rods, cones …