Breast cancer is immunogenic, and infiltrating immune cells in primary breast tumors convey
important clinical prognostic and predictive information. Furthermore, the immune system is …

Since the discovery, over a decade and a half ago, that genetically engineered DNA can be
delivered in vaccine form and elicit an immune response, there has been much progress in …

Inflammatory cell infiltration of tumors contributes either positively or negatively to tumor
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …

Despite tremendous progress in basic and epidemiological research, effective prevention of
most types of cancer is still lacking. Vaccine use in cancer therapy remains a promising but …

New local treatments based on electromagnetic fields have been developed as non‐
surgical and minimally invasive treatments of tumors. In particular, short electric pulses can …

Nonviral gene transfer is markedly enhanced by the application of in vivo electroporation
(also denoted electrogene transfer or electrokinetic enhancement). This approach is safe …

Our goal is to develop peptide vaccines that stimulate tumor antigen–specific T-cell
responses against frequently found cancers. Previous work has shown that to generate …

Transdermal administration of drugs has advantages over conventional oral administration
or administration using injection equipment. The route of administration reduces the …

The expectation has been that plasmid DNA vaccines may have use against a wide range of
microbial and oncologic targets. However, attempts at their development have been …

Endogenous angiogenesis inhibitors have shown promise in preclinical trials, but clinical
use has been hindered by low half-life in circulation and high production costs. Here, we …