The hair bundle—the sensory organelle of inner-ear hair cells of vertebrates—exemplifies
the ability of a cell to assemble complex, elegant structures. Proper construction of the …

Acquisition of cell polarity generates signaling and cytoskeletal asymmetry and thus
underpins polarized cell behaviors during tissue morphogenesis. In epithelial tissues, both …

Inner ear vestibular and spiral ganglion neurons (VGNs and SGNs) are known to play
pivotal roles in balance control and sound detection. However, the molecular mechanisms …

Hair cells detect sound, head position or water movements when their mechanosensory hair
bundle is deflected. Each hair bundle has an asymmetric architecture that restricts stimulus …

The utricle of the inner ear, a vestibular sensory structure that mediates perception of linear
acceleration, is comprised of two morphologically and physiologically distinct types of …

The transduction compartment of inner ear hair cells, the hair bundle, is composed of
stereocilia rows of graded height, a property essential for sensory function that remains …

Planar cell polarity (PCP) plays crucial roles in developmental processes such as
gastrulation, neural tube closure and hearing. Wnt pathway mutants are often classified as …

The distinctive planar polarity of auditory hair cells is evident in the polarized organization of
the stereociliary bundle. Mutations in the core planar cell polarity gene Van Gogh-like 2 …

Planar polarity describes the organization and orientation of polarized cells or cellular
structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate …

In the inner ear sensory epithelia, stereociliary hair bundles atop sensory hair cells are
mechanosensory apparatus with planar polarized structure and orientation. This is …