[HTML][HTML] Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

YT Lee, YJ Tan, CE Oon - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Cancer is the second leading cause of mortality globally which remains a continuing threat
to human health today. Drug insensitivity and resistance are critical hurdles in cancer …

New therapies for advanced thyroid cancer

D Laha, N Nilubol, M Boufraqech - Frontiers in endocrinology, 2020 - frontiersin.org
Thyroid cancer is the most common endocrine cancer. The discovery of new biomarkers for
thyroid cancer has significantly improved the understanding of the molecular pathogenesis …

Updates on the management of thyroid cancer

KA Araque, S Gubbi… - Hormone and …, 2020 - thieme-connect.com
The diagnostic modalities, stratification tools, and treatment options for patients with thyroid
cancer have rapidly evolved since the development of the American Thyroid Association …

Novel targeted therapies for metastatic thyroid cancer—a comprehensive review

M Al-Jundi, S Thakur, S Gubbi, J Klubo-Gwiezdzinska - Cancers, 2020 - mdpi.com
The knowledge on thyroid cancer biology has grown over the past decade. Thus, diagnostic
and therapeutic strategies to manage thyroid cancer are rapidly evolving. With new insights …

Redifferentiation of radioiodine-refractory thyroid cancers

C Buffet, J Wassermann, F Hecht… - Endocrine-Related …, 2020 - erc.bioscientifica.com
The management of radioiodine refractory thyroid cancers (RAIR TC) is challenging for the
clinician. Tyrosine kinase inhibitors classically prescribed in this setting can fail due to …

Redifferentiation-facilitated radioiodine therapy in thyroid cancer

L Lamartina, N Anizan, C Dupuy… - Endocrine-Related …, 2021 - erc.bioscientifica.com
Based on experimental data, the inhibition of the MAPkinase pathway in patients with
radioiodine-refractory thyroid cancer was capable of inducing a redifferentiation. Preliminary …

An update of new small-molecule anticancer drugs approved from 2015 to 2020

X Liang, P Wu, Q Yang, Y Xie, C He, L Yin, Z Yin… - European Journal of …, 2021 - Elsevier
A high incidence of cancer has given rise to the development of more anti-tumor drugs. From
2015 to 2020, fifty-six new small-molecule anticancer drugs, divided into ten categories …

Standardised quantitative radioiodine SPECT/CT imaging for multicentre dosimetry trials in molecular radiotherapy

RA Gregory, I Murray, J Gear, F Leek… - Physics in Medicine …, 2019 - iopscience.iop.org
Abstract The SEL-I-METRY trial (EudraCT No 2015-002269-47) is the first multicentre trial to
investigate the role of 123 I and 131 I SPECT/CT-based tumour dosimetry to predict …

Cellular plasticity in breast cancer progression and therapy

D Kong, CJ Hughes, HL Ford - Frontiers in molecular biosciences, 2020 - frontiersin.org
With the exception of non-melanoma skin cancer, breast cancer is the most frequently
diagnosed malignant disease among women, with the majority of mortality being attributable …

Redox Homeostasis in Thyroid Cancer: Implications in Na+/I Symporter (NIS) Regulation

J Cazarin, C Dupuy, D Pires de Carvalho - International journal of …, 2022 - mdpi.com
Radioiodine therapy (RAI) is a standard and effective therapeutic approach for differentiated
thyroid cancers (DTCs) based on the unique capacity for iodide uptake and accumulation of …