RNA velocity—current challenges and future perspectives
RNA velocity has enabled the recovery of directed dynamic information from single‐cell
transcriptomics by connecting measurements to the underlying kinetics of gene expression …
transcriptomics by connecting measurements to the underlying kinetics of gene expression …
Local immune recognition of trophoblast in early human pregnancy: controversies and questions
A Moffett, N Shreeve - Nature Reviews Immunology, 2023 - nature.com
The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …
controversial. Here we focus on the events that occur in the maternal decidua during the first …
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes
N Chaudhary, AN Newby, ML Arral… - Proceedings of the …, 2024 - National Acad Sciences
Treating pregnancy-related disorders is exceptionally challenging because the threat of
maternal and/or fetal toxicity discourages the use of existing medications and hinders new …
maternal and/or fetal toxicity discourages the use of existing medications and hinders new …
[HTML][HTML] Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene
Maternal-offspring interactions in mammals involve both cooperation and conflict. The fetus
has evolved ways to manipulate maternal physiology to enhance placental nutrient transfer …
has evolved ways to manipulate maternal physiology to enhance placental nutrient transfer …
Establishment of fetomaternal tolerance through glycan-mediated B cell suppression
Discrimination of self from non-self is fundamental to a wide range of immunological
processes. During pregnancy, the mother does not recognize the placenta as …
processes. During pregnancy, the mother does not recognize the placenta as …
Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B
S Andrews, C Krueger, M Mellado-Lopez… - Nature …, 2023 - nature.com
DNA methylation is a repressive epigenetic modification that is essential for development,
exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA …
exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA …
Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes
AR Ringel, Q Szabo, AM Chiariello, K Chudzik… - Cell, 2022 - cell.com
Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …
unclear how their integrity is maintained when incorporating novel genes and functions …
Alevin-fry unlocks rapid, accurate and memory-frugal quantification of single-cell RNA-seq data
The rapid growth of high-throughput single-cell and single-nucleus RNA-sequencing
(scRNA-seq and snRNA-seq) technologies has produced a wealth of data over the past few …
(scRNA-seq and snRNA-seq) technologies has produced a wealth of data over the past few …
A comprehensive review of human trophoblast fusion models: recent developments and challenges
X Li, ZH Li, YX Wang, TH Liu - Cell Death Discovery, 2023 - nature.com
As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …
layer contributes to a successful pregnancy by secreting hormones necessary for …