Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and
leukotrienes, impact the immune system, usually as proinflammatory factors. Other …

The gastrointestinal tract harbours the largest population of mast cells in the body; this highly
specialised leukocyte cell type is able to adapt its phenotype and function to the …

The gut microbiota has been implicated in chronic pain disorders, including irritable bowel
syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed …

Background The anti-inflammatory property of ω-3 polyunsaturated fatty acids (PUFA) has
been exploited in the management of inflammatory bowel disease (IBD) with promising …

Histamine is a natural amine derived from L-histidine. Although it seems that our knowledge
about this molecule is wide and diverse, the importance of histamine in many regulatory …

Mast cells are immune cells which have a widespread distribution in nearly all tissues.
These cells and their mediators are canonically viewed as primary effector cells in allergic …

Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public
health concern. It is generally acknowledged that a variety of factors play a role in the …

Background & Aims Recent literature has implicated a key role for mast cells in murine
models of colonic inflammation, but their role in human ulcerative colitis (UC) is not well …

Mast cells are often regarded through the lens of IgE-dependent reactions as a cell
specialized only for anti-parasitic and type I hypersensitive responses. However, recently …

Background Crohn's disease (CD) has an increasing incidence and prevalence worldwide.
It is currently believed that both the onset and progression of the disease are closely related …