Leishmania tarentolae: a vaccine platform to target dendritic cells and a surrogate pathogen for next generation vaccine research in leishmaniases and viral …

C Bandi, JA Mendoza-Roldan, D Otranto, A Alvaro… - Parasites & …, 2023 - Springer
Parasites of the genus Leishmania are unusual unicellular microorganisms in that they are
characterized by the capability to subvert in their favor the immune response of mammalian …

Host–pathogen interaction in leishmaniasis: immune response and vaccination strategies

H Yasmin, A Adhikary, MN Al-Ahdal, S Roy, U Kishore - Immuno, 2022 - mdpi.com
Leishmaniasis is a zoonotic and vector-borne infectious disease that is caused by the genus
Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic …

Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases

JA Mendoza‐Roldan, J Votýpka… - Transboundary and …, 2022 - Wiley Online Library
Leishmaniasis (or the leishmaniases), classified as a neglected tropical parasitic disease, is
found in parts of the tropics, subtropics and southern Europe. Leishmania parasites are …

Global distribution of treatment resistance gene markers for leishmaniasis

S Salari, M Bamorovat, I Sharifi… - Journal of Clinical …, 2022 - Wiley Online Library
Abstract Background Pentavalent antimonials (Sb (V)) such as meglumine antimoniate
(Glucantime®) and sodium stibogluconate (Pentostam®) are used as first‐line treatments for …

New Approaches to the Prevention of Visceral Leishmaniasis: A Review of Recent Patents of Potential Candidates for a Chimeric Protein Vaccine

DS Oliveira, MF Zaldívar, AAM Gonçalves, LA Resende… - Vaccines, 2024 - mdpi.com
The development of prophylactic vaccines is important in preventing and controlling
diseases such as visceral leishmaniasis (VL), in addition to being an economic measure for …

Leishmania tarentolae as Potential Live Vaccine Co-Expressing Distinct Salivary Gland Proteins Against Experimental Cutaneous Leishmaniasis in BALB/c Mice …

MS Lajevardi, E Gholami, T Taheri, H Sarvnaz… - Frontiers in …, 2022 - frontiersin.org
Leishmaniasis is a neglected vector-borne disease caused by Leishmania parasites
transmitted through the infected sand flies bite. Current treatments are limited, partly due to …

In vitro and in vivo study on antiprotozoal activity of calcium oxide (CaO) and magnesium oxide (MgO) nanoparticles on promastigote and amastigote forms of …

AD Ghaffari, M Barati, A KarimiPourSaryazdi… - Acta Tropica, 2023 - Elsevier
Background: Currently, anti-leishmanial drugs have been developed. However, the
available compounds have several side effects such as drug resistance and toxicity that …

Leishmania tarentolae as an Antigen Delivery Platform: Dendritic Cell Maturation after Infection with a Clone Engineered to Express the SARS-CoV-2 Spike Protein

I Varotto-Boccazzi, M Garziano, GM Cattaneo… - Vaccines, 2022 - mdpi.com
Background: Protozoa of the genus Leishmania are characterized by their capacity to target
macrophages and Dendritic Cells (DCs). These microorganisms could thus be exploited for …

Identification of immunodominant antigens from a first-generation vaccine against cutaneous leishmaniasis

MJ Germanó, JP Mackern-Oberti, JG Vitório… - Frontiers in …, 2022 - frontiersin.org
Leishmaniasis is a neglected tropical disease (NTD) caused by parasites belonging to the
Leishmania genus for which there is no vaccine available for human use. Thus, the aims of …

Preclinical safety evaluation of a bivalent inactivated EV71-CA16 vaccine in mice immunized intradermally

Y Liao, Q Jiang, X Huo, L Yu, J Yang… - Human Vaccines & …, 2023 - Taylor & Francis
Hand, foot and mouth disease is a common acute viral infectious disease that poses a
serious threat to the life and health of young children. With the development of an effective …