The impact of targeted therapies in glioma has been modest. All the therapies that have
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …

Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …

Importance Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for
glioblastoma remain poor, and new treatments are needed. Objective To investigate …

We present an extensive assessment of mutation burden through sequencing analysis of>
81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused …

Purpose Recurrent glioblastoma multiforme (GBM) is incurable with current therapies.
Biallelic mismatch repair deficiency (bMMRD) is a highly penetrant childhood cancer …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

We present the case of a patient with a left frontal glioblastoma with primitive
neuroectodermal tumor features and hypermutated genotype in the setting of a POLE …

Purpose To evaluate the association of multiparametric and multiregional magnetic
resonance (MR) imaging features with key molecular characteristics in patients with newly …

The evolutionary history of tumor cell populations can be reconstructed from patterns of
genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and …

Low-grade gliomas cause considerable morbidity and most will recur after initial therapy. At
recurrence, low-grade gliomas can undergo transformation to high-grade gliomas (grade III …