Repetitive elements in aging and neurodegeneration
KE Copley, J Shorter - Trends in Genetics, 2023 - cell.com
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …
Retrotransposons as a Source of DNA Damage in Neurodegeneration
E Peze-Heidsieck, T Bonnifet, R Znaidi… - Frontiers in aging …, 2022 - frontiersin.org
The etiology of aging-associated neurodegenerative diseases (NDs), such as Parkinson's
disease (PD) and Alzheimer's disease (AD), still remains elusive and no curative treatment …
disease (PD) and Alzheimer's disease (AD), still remains elusive and no curative treatment …
Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain
Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-
associated decline in organ functions in mammals; however, the specific cell types and gene …
associated decline in organ functions in mammals; however, the specific cell types and gene …
Transposable elements generate regulatory novelty in a tissue-specific fashion
M Trizzino, A Kapusta, CD Brown - BMC genomics, 2018 - Springer
Background Transposable elements (TE) are an important source of evolutionary novelty in
gene regulation. However, the mechanisms by which TEs contribute to gene expression are …
gene regulation. However, the mechanisms by which TEs contribute to gene expression are …
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
GC Pereira, L Sanchez, PM Schaughency… - Mobile Dna, 2018 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
The role of transposable elements of the human genome in neuronal function and pathology
E Chesnokova, A Beletskiy, P Kolosov - International Journal of …, 2022 - mdpi.com
Transposable elements (TEs) have been extensively studied for decades. In recent years,
the introduction of whole-genome and whole-transcriptome approaches, as well as single …
the introduction of whole-genome and whole-transcriptome approaches, as well as single …
Novel bioinformatics approach identifies transcriptional profiles of lineage-specific transposable elements at distinct loci in the human dorsolateral prefrontal cortex
Expression of transposable elements (TE) is transiently activated during human
preimplantation embryogenesis in a developmental stage-and cell type-specific manner and …
preimplantation embryogenesis in a developmental stage-and cell type-specific manner and …
Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors
The hippocampus is associated with essential brain functions, such as learning and
memory. Human hippocampal volume is significantly greater than expected compared with …
memory. Human hippocampal volume is significantly greater than expected compared with …
Long Interspersed Nuclear Element-1 Analytes in Extracellular Vesicles as Tools for Molecular Diagnostics of Non-Small Cell Lung Cancer
EC Bowers, AM Cavalcante, K Nguyen, C Li… - International Journal of …, 2024 - mdpi.com
Aberrant expression of the oncogenic retrotransposon LINE-1 is a hallmark of various
cancer types, including non-small cell lung cancers (NSCLCs). Here, we present proof-of …
cancer types, including non-small cell lung cancers (NSCLCs). Here, we present proof-of …
LINE-1 cargo and reverse transcriptase activity profiles in extracellular vesicles from lung cancer cells and human plasma
EC Bowers, A Motta, K Knox, BS McKay… - International Journal of …, 2022 - mdpi.com
Long Interspersed Element-1 (LINE-1) is an oncogenic human retrotransposon that 'copies
and pastes' DNA into new locations via reverse transcription. Given that enzymatically active …
and pastes' DNA into new locations via reverse transcription. Given that enzymatically active …