[HTML][HTML] The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities
AH Schmaier - Journal of Thrombosis and Haemostasis, 2016 - Elsevier
The contact activation system (CAS) and kallikrein/kinin system (KKS) are older recognized
biochemical pathways that include several proteins that skirt the fringes of the blood …
biochemical pathways that include several proteins that skirt the fringes of the blood …
Strategies to improve plasma half life time of peptide and protein drugs
M Werle, A Bernkop-Schnürch - Amino acids, 2006 - Springer
Due to the obvious advantages of long-acting peptide and protein drugs, strategies to
prolong plasma half life time of such compounds are highly on demand. Short plasma half …
prolong plasma half life time of such compounds are highly on demand. Short plasma half …
Ang II (angiotensin II) conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2) …
P Serfozo, J Wysocki, G Gulua, A Schulze, M Ye… - …, 2020 - Am Heart Assoc
The Ang II (Angiotensin II)-Angiotensin-(1-7) axis of the Renin Angiotensin System
encompasses 3 enzymes that form Angiotensin-(1-7)[Ang-(1-7)] directly from Ang II: ACE2 …
encompasses 3 enzymes that form Angiotensin-(1-7)[Ang-(1-7)] directly from Ang II: ACE2 …
[HTML][HTML] The dipeptidyl peptidase family, prolyl oligopeptidase, and prolyl carboxypeptidase in the immune system and inflammatory disease, including atherosclerosis
Y Waumans, L Baerts, K Kehoe, AM Lambeir… - Frontiers in …, 2015 - frontiersin.org
Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its
family members in many processes and different pathologies of the immune system. Most …
family members in many processes and different pathologies of the immune system. Most …
Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
BB Gao, A Clermont, S Rook, SJ Fonda… - Nature medicine, 2007 - nature.com
Excessive retinal vascular permeability contributes to the pathogenesis of proliferative
diabetic retinopathy and diabetic macular edema, leading causes of vision loss in working …
diabetic retinopathy and diabetic macular edema, leading causes of vision loss in working …
Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations
The transition from land to water in whales and dolphins (cetaceans) was accompanied by
remarkable adaptations. To reveal genomic changes that occurred during this transition, we …
remarkable adaptations. To reveal genomic changes that occurred during this transition, we …
[HTML][HTML] The intrinsic pathway of coagulation: a target for treating thromboembolic disease?
D Gailani, T Renne - Journal of Thrombosis and Haemostasis, 2007 - Elsevier
The classic intrinsic pathway of coagulation is triggered by contact activation of the plasma
protease factor (F) XII, followed by sequential proteolytic activation of FX1 and FIX. While a …
protease factor (F) XII, followed by sequential proteolytic activation of FX1 and FIX. While a …
Human plasma kallikrein-kinin system: physiological and biochemical parameters
JW Bryant, Z Shariat-Madar - Cardiovascular & Hematological …, 2009 - ingentaconnect.com
The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …
[HTML][HTML] The elusive physiologic role of Factor XII
AH Schmaier - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
Physiologic hemostasis upon injury involves many plasma proteins in a well-regulated
cascade of proteolytic reactions to form a clot. Deficiency of blood coagulation Factors VIII …
cascade of proteolytic reactions to form a clot. Deficiency of blood coagulation Factors VIII …
Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology
IM Sainz, RA Pixley, RW Colman - Thrombosis and …, 2007 - thieme-connect.com
F or forty years my laboratory has been studying the kallikrein-kininogen-kinin system (KKS).
I was challenged by my mentor Dr. Sol Sherry in whose laboratory I was completing my …
I was challenged by my mentor Dr. Sol Sherry in whose laboratory I was completing my …