Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing
and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus …

The deposition of chemical modifications into RNA is a crucial regulator of temporal and
spatial gene expression programs during development. Accordingly, altered RNA …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

Maintaining proteostasis is key to resisting stress and promoting healthy aging. Proteostasis
is necessary to preserve stem cell function, but little is known about the mechanisms that …

Hematopoietic stem cells (HSCs) adapt their metabolism to maintenance and proliferation;
however, the mechanism remains incompletely understood. Here, we demonstrated that …