The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders
M Kokkinou, AH Ashok, OD Howes - Molecular psychiatry, 2018 - nature.com
Ketamine is a non-competitive antagonist at the N-methyl-d-aspartate receptor. It has
recently been found to have antidepressant effects and is a drug of abuse, suggesting it may …
recently been found to have antidepressant effects and is a drug of abuse, suggesting it may …
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
TH Pham, AM Gardier - Pharmacology & therapeutics, 2019 - Elsevier
Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
NMDAR hypofunction animal models of schizophrenia
The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …
Altered cortical ensembles in mouse models of schizophrenia
In schizophrenia, brain-wide alterations have been identified at the molecular and cellular
levels, yet how these phenomena affect cortical circuit activity remains unclear. We studied …
levels, yet how these phenomena affect cortical circuit activity remains unclear. We studied …
Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and “depressed” mice exposed to chronic mild stress
A Franceschelli, J Sens, S Herchick, C Thelen… - Neuroscience, 2015 - Elsevier
During the past decade, one of the most striking discoveries in the treatment of major
depression was the clinical finding that a single infusion of a sub-anesthetic dose of the N …
depression was the clinical finding that a single infusion of a sub-anesthetic dose of the N …
Ketamine rapidly enhances glutamate-evoked dendritic spinogenesis in medial prefrontal cortex through dopaminergic mechanisms
Background Ketamine elicits rapid onset antidepressant effects in patients with clinical
depression through mechanisms hypothesized to involve the genesis of neocortical …
depression through mechanisms hypothesized to involve the genesis of neocortical …
Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions
Escaping aversive stimuli is essential for complex organisms, but prolonged exposure to
stress leads to maladaptive learning. Stress alters neuronal activity and neuromodulatory …
stress leads to maladaptive learning. Stress alters neuronal activity and neuromodulatory …
Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: possible involvement of antioxidant and nitrergic pathways
AS Monte, GC de Souza, RS McIntyre… - Journal of …, 2013 - journals.sagepub.com
It has been hypothesized that oxidative imbalance and alterations in nitrergic signaling play
a role in the neurobiology of schizophrenia. Preliminary evidence suggests that adjunctive …
a role in the neurobiology of schizophrenia. Preliminary evidence suggests that adjunctive …
Reversal and preventive pleiotropic mechanisms involved in the antipsychotic-like effect of taurine, an essential β-amino acid in ketamine-induced experimental …
Schizophrenia is a life disabling, multisystem neuropsychiatric disease mostly derived from
complex epigenetic-mediated neurobiological changes causing behavioural deficits …
complex epigenetic-mediated neurobiological changes causing behavioural deficits …
New paradigms for treatment‐resistant depression
Clinical depression is a serious mental disorder characterized by low mood, anhedonia, loss
of interest in daily activities, and other symptoms, and is associated with severe …
of interest in daily activities, and other symptoms, and is associated with severe …