Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms,
are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and …

Oritavancin (LY333328) is a semisynthetic glycopeptide antibiotic having excellent
bactericidal activity against glycopeptide-susceptible and-resistant Gram-positive bacteria …

The emergence and spread of multidrug-resistant gram-positive bacteria represent a serious
clinical problem. Telavancin is a novel lipoglycopeptide antibiotic that possesses rapid in …

Vancomycin and teicoplanin are still the only glycopeptide antibiotics available for use in
humans. Emergence of resistance in enterococci and staphylococci has led to restriction of …

Telavancin, a derivative of vancomycin, is a lipoglycopeptide antibiotic that has been shown
to be effective for the treatment of complicated skin and skin-structure infections. It has also …

The vancomycin family of glycopeptide antibiotics has been inspiring research in the field of
synthetic chemistry since the 1980s. Recent studies have moved away from the focus of total …

High through put screening (HTS) was extensively used in attempts to discover new TB
drugs from libraries of pure small molecule compounds many of which complied with the …

Over the past forty years, efforts to discover antibacterials have yielded a wide variety of
chemical structures, almost exclusively natural products, which inhibit many steps in cell wall …

Solid-state NMR has been used to examine isolated cell walls and intact whole cells of
Staphylococcus aureus complexed to five different vancomycin, eremomycin, and …

A variety of semisynthetic derivatives of natural antibacterial glycopeptide antibiotics such as
vancomycin, eremomycin, ristocetin A, teicoplanin A2-2, DA-40926, their aglycons, and also …