It has long been believed that the lysosome is an important digestive organelle. There is
increasing evidence that the lysosome is also involved in pathogenesis of a variety of …

Niemann-Pick type C disease (NPC) is characterized by neurodegeneration secondary to
impaired cholesterol trafficking and excessive glycosphingolipid storage. Abnormal …

Endolysosomal proteases such as cysteinyl and aspartyl cathepsins play diverse roles in
inflammatory autoimmune diseases, cancers, and neurodegenerative diseases. Cysteinyl …

Previous reports suggest that age-related lysosomal disturbances contribute to Alzheimer-
type accumulations of protein species, blockage of axonal/dendritic transport, and synaptic …

In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The
intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long …

Many synapses contain two types of receptors–integrins and N-methyl-D-aspartate (NMDA)
receptors–that have been implicated in peptide internalization. The present studies tested if …

N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in
vitro. Mutant htt expression stimulates autophagy and increases levels of lysosomal …

Lysosomal disturbances may be a contributing factor to Alzheimer's disease. We used novel
compounds to test if suppression of the lysosomal protease cathepsin D blocks production of …

Alzheimer's disease (AD), a neurodegenerative disorder that can occur in middle or old age,
is characterized by memory loss, a continuous decline in thinking, behavioral and social …

Cathepsin D is a lysosomal endoproteolytic aspartic proteinase which also has been found
in endosomes of macrophage. It is thought to play key roles in the developmental and …