In this paper we report, clarify and broaden various recent efforts to complement the
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …

Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …

Tissue cells sense and respond to the stiffness of the surface on which they adhere.
Precisely how cells sense surface stiffness remains an open question, though various …

Under the microscope, eukaryotic animal cells can adopt a variety of different shapes and
sizes. These cells also move and deform, and the physical mechanisms driving these …

In contracting muscle, individual myosin molecules function as part of a large ensemble,
hydrolyzing ATP to power the relative sliding of actin filaments. The technological advances …

We present a model describing friction due to the thermally activated formation and rupture
of molecular bonds between two surfaces, with long molecules on one surface attaching to …

The loss of muscle force and power during fatigue from intense contractile activity is
associated with, and likely caused by, elevated levels of phosphate (P _ i P i) and hydrogen …

Cardiovascular diseases account for the number one cause of deaths in the world. Part of
the reason for such grim statistics is our limited understanding of the underlying mechanisms …

A skeletal muscle that is stretched while contracting will produce more force at steady state
than if it is stretched passively and then stimulated to contract. This phenomenon is known …

Models of muscle contraction fall into two broad categories: those that attempt to describe
the molecules that power muscle contraction and those that posit relationships between …