The plasma membrane (PM) performs a plethora of physiological processes, the
coordination of which requires spatial and temporal organization into specialized domains of …

Cell nutrition, detoxification, signalling, homeostasis and response to drugs, processes
related to cell growth, differentiation and survival are all mediated by plasma membrane …

The uric acid/xanthine H+ symporter, UapA, is a high-affinity purine transporter from the
filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a …

After endocytosis, membrane proteins can recycle to the cell membrane or be degraded in
lysosomes. Cargo ubiquitylation favors their lysosomal targeting and can be regulated by …

Nutrient availability controls the landscape of nutrient transporters present at the plasma
membrane, notably by regulating their ubiquitylation and subsequent endocytosis. In yeast …

The role of membrane lipids in modulating eukaryotic transporter assembly and function
remains unclear. We investigated the effect of membrane lipids in the structure and transport …

Transporters are ubiquitous proteins mediating the translocation of solutes across cell
membranes, a biological process involved in nutrition, signaling, neurotransmission, cell …

NCS 1 proteins are H+/Na+ symporters specific for the uptake of purines, pyrimidines and
related metabolites. In this article, we study the origin, diversification and substrate specificity …

Filamentous fungi provide excellent systems for investigating the role of the AP-2 complex in
polar growth. Using Aspergillus nidulans, we show that AP-2 has a clathrin-independent …

Plasma membrane transporters play pivotal roles in the import of nutrients, including sugars,
amino acids, nucleobases, carboxylic acids, and metal ions, that surround fungal cells. The …