Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and
glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian …

Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Cancer with heavily economic and social burden is the hot point in the field of medical
research. Some remarkable achievements have been made; however, the exact …

KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC).
Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 …

Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …

The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer
Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been …

Background Advances in the high-throughput omic technologies have made it possible to
profile cells in a large number of ways at the DNA, RNA, protein, chromosomal, functional …

Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to
asparagine and glutamate in an ATP-dependent reaction. The enzyme is ubiquitous in its …

Molecular diagnostics, the use of diagnostic testing to understand the molecular
mechanisms of an individual patient's disease, will be pivotal in the delivery of safe and …

In vitro human cell line models have been widely used for cancer pharmacogenomic studies
to predict clinical response, to help generate pharmacogenomic hypothesis for further …