Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

[HTML][HTML] Recent advances in metabolomics analysis for early drug development

JC Alarcon-Barrera, S Kostidis, A Ondo-Mendez… - Drug discovery today, 2022 - Elsevier
Highlights•Metabolomics has become a widely applied tool in drug development.•
Metabolomics plays a key role for the identification of physiological response markers.• …

Metabolic dynamics and prediction of gestational age and time to delivery in pregnant women

L Liang, MLH Rasmussen, B Piening, X Shen, S Chen… - Cell, 2020 - cell.com
Metabolism during pregnancy is a dynamic and precisely programmed process, the failure
of which can bring devastating consequences to the mother and fetus. To define a high …

Emerging applications of metabolomics in drug discovery and precision medicine

DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …

Metabolomics enables precision medicine:“a white paper, community perspective”

RD Beger, W Dunn, MA Schmidt, SS Gross, JA Kirwan… - Metabolomics, 2016 - Springer
Abstract Introduction: Background to metabolomics Metabolomics is the comprehensive
study of the metabolome, the repertoire of biochemicals (or small molecules) present in …

Metabolomics: a primer

X Liu, JW Locasale - Trends in biochemical sciences, 2017 - cell.com
Metabolomics generates a profile of small molecules that are derived from cellular
metabolism and can directly reflect the outcome of complex networks of biochemical …

Analytical methods in untargeted metabolomics: state of the art in 2015

A Alonso, S Marsal, A Julià - Frontiers in bioengineering and …, 2015 - frontiersin.org
Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …

Predicting network activity from high throughput metabolomics

S Li, Y Park, S Duraisingham, FH Strobel… - PLoS computational …, 2013 - journals.plos.org
The functional interpretation of high throughput metabolomics by mass spectrometry is
hindered by the identification of metabolites, a tedious and challenging task. We present a …

Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases

YV Sun, YJ Hu - Advances in genetics, 2016 - Elsevier
Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …

Spatial metabolomics and imaging mass spectrometry in the age of artificial intelligence

T Alexandrov - Annual review of biomedical data science, 2020 - annualreviews.org
Spatial metabolomics is an emerging field of omics research that has enabled localizing
metabolites, lipids, and drugs in tissue sections, a feat considered impossible just two …