Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia
M Xu, S Wu, Y Wang, Y Zhao, X Wang, C Wei… - Frontiers in …, 2022 - frontiersin.org
Methotrexate (MTX) is a folic acid antagonist, the mechanism of action is to inhibit DNA
synthesis, repair and cell proliferation by decreasing the activities of several folate …
synthesis, repair and cell proliferation by decreasing the activities of several folate …
Genetic susceptibility in childhood acute lymphoblastic leukemia
A Gutierrez-Camino, I Martin-Guerrero, A García-Orad - Medical Oncology, 2017 - Springer
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a
leading cause of death due to disease in children. The genetic basis of ALL susceptibility …
leading cause of death due to disease in children. The genetic basis of ALL susceptibility …
[PDF][PDF] Islam and Islamic institutions in British Malaya: policies and implementation
M Yegar - 1979 - scholar.archive.org
Hematopoesis is a multi-stage process, which results in development of blood and immande
system's cells. Ikaros, which is coded by IKZF1 and Ikaros faimily zinc finger transcription …
system's cells. Ikaros, which is coded by IKZF1 and Ikaros faimily zinc finger transcription …
ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis
WZ Leong, SH Tan, PCT Ngoc, S Amanda… - Genes & …, 2017 - genesdev.cshlp.org
The oncogenic transcription factor TAL1/SCL induces an aberrant transcriptional program in
T-cell acute lymphoblastic leukemia (T-ALL) cells. However, the critical factors that are …
T-cell acute lymphoblastic leukemia (T-ALL) cells. However, the critical factors that are …
The role of ARID5B in acute lymphoblastic leukemia and beyond
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children with distinct
characteristics among different subtypes. Although the etiology of ALL has not been fully …
characteristics among different subtypes. Although the etiology of ALL has not been fully …
[HTML][HTML] Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk
A Gutierrez-Camino, I Martin-Guerrero, V Dolzan… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous
studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays …
studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays …
Association of genetic variants in ARID5B, IKZF1 and CEBPE with risk of childhood de novo B-lineage acute lymphoblastic leukemia in India
P Bhandari, F Ahmad, S Mandava - Asian Pacific Journal of …, 2016 - journal.waocp.org
Background Childhood acute lymphoblastic leukemia (ALL) is a heterogeneous genetic
disease and its etiology remains poorly understood. Recent genome wide association and …
disease and its etiology remains poorly understood. Recent genome wide association and …
[PDF][PDF] Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population
M Kreile, L Piekuse, D Rots, Z Dobele… - Archives of Medical …, 2016 - termedia.pl
Results: We identified the SNP rs10821936 in the ARID5B gene as being statistically
significantly associated with childhood ALL, especially if the C allele is in a homozygous …
significantly associated with childhood ALL, especially if the C allele is in a homozygous …
Association of genetic variation in IKZF1, ARID5B, CDKN2A, and CEBPE with the risk of acute lymphoblastic leukemia in Tunisian children and their contribution to …
H Gharbi, I Ben Hassine, I Soltani, I Safra… - Pediatric hematology …, 2016 - Taylor & Francis
Recent genome-wide association studies (GWAS) focusing on pediatric acute lymphoblastic
leukemia (ALL), the most common malignancy in children younger than 15 years old, have …
leukemia (ALL), the most common malignancy in children younger than 15 years old, have …
Confirmation of involvement of new variants at CDKN2A/B in pediatric acute lymphoblastic leukemia susceptibility in the Spanish population
A Gutierrez-Camino, I Martin-Guerrero… - PLoS …, 2017 - journals.plos.org
The locus CDKN2A/B (9p21. 3), which comprises the tumor suppressors genes CDKN2A
and CDKN2B and the long noncoding RNA (lncRNA) known as ANRIL (or CDKN2B-AS) …
and CDKN2B and the long noncoding RNA (lncRNA) known as ANRIL (or CDKN2B-AS) …