Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …

The treatment of long-gap (> 10 mm) peripheral nerve injury (PNI) and spinal cord injury
(SCI) remains a continuous challenge due to limited native tissue regeneration capabilities …

Engineering hierarchical vasculatures is critical for creating implantable functional thick
tissues. Current approaches focus on fabricating mesoscale vessels for implantation or …

Extracellular vesicles (EVs) have emerged as a promising strategy to promote tissue
regeneration. However, overcoming the low EV production yield remains a big challenge in …

Dental stem cells (DSCs), an important source of mesenchymal stem cells (MSCs), can be
easily obtained by minimally invasive procedures and have been used for the treatment of …

Spinal cord injury (SCI) is a debilitating condition, often leading to severe motor, sensory, or
autonomic nervous dysfunction. As the holy grail of regenerative medicine, promoting spinal …

Peripheral nerve and spinal cord injuries are potentially devastating traumatic conditions
with major consequences for patients' lives. Severe cases of these conditions are currently …

Tissue engineering strategy that combine biomaterials with living cells has shown special
advantages in tissue regeneration and promoted the development of regenerative medicine …

The spinal cord and the brain form the central nervous system (CNS), which is the most
important part of the body. However, spinal cord injury (SCI) caused by external forces is …

A functional multi-scale vascular network can promote 3D engineered tissue growth and
improve transplantation outcome. In this work, by using a combination of living cells …