DNA origami

S Dey, C Fan, KV Gothelf, J Li, C Lin, L Liu… - Nature Reviews …, 2021 - nature.com
Biological materials are self-assembled with near-atomic precision in living cells, whereas
synthetic 3D structures generally lack such precision and controllability. Recently, DNA …

Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

[HTML][HTML] Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats

J Hou, Z Lei, L Cui, Y Hou, L Yang, R An… - Ecotoxicology and …, 2021 - Elsevier
Microplastics (MPs) considered as a new persistent environmental pollutant could enter into
the circulatory system and result in decrease of sperm quantity and quality in mice. However …

Nanogels: Synthesis, properties, and recent biomedical applications

QY Duan, YX Zhu, HR Jia, SH Wang, FG Wu - Progress in Materials …, 2023 - Elsevier
Nanogels, also termed hydrogel nanoparticles, have the properties and functions of both
nanomaterials and hydrogels. Till date, a considerable number of nanogels have been …

A tubular DNA nanodevice as a siRNA/chemo‐drug co‐delivery vehicle for combined cancer therapy

Z Wang, L Song, Q Liu, R Tian, Y Shang… - Angewandte …, 2021 - Wiley Online Library
Using the DNA origami technique, we constructed a DNA nanodevice functionalized with
small interfering RNA (siRNA) within its inner cavity and the chemotherapeutic drug …

[HTML][HTML] Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis

M Zhao, R Wang, K Yang, Y Jiang, Y Peng, Y Li… - … Pharmaceutica Sinica B, 2023 - Elsevier
RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …

[HTML][HTML] Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer

Y Liang, Y Wang, L Wang, Z Liang, D Li, X Xu, Y Chen… - Bioactive materials, 2021 - Elsevier
Bladder cancer is one of the concerning malignancies worldwide, which is lacking effective
targeted therapy. Gene therapy is a potential approach for bladder cancer treatment. While …

Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages

X Huang, C Liu, N Kong, Y Xiao, A Yurdagul Jr… - Nature protocols, 2022 - nature.com
Macrophages in atherosclerotic lesions promote plaque progression and are an attractive
therapeutic target in cardiovascular research. Here we present a protocol for synthesis of …

DNA nanostructures: current challenges and opportunities for cellular delivery

A Lacroix, HF Sleiman - ACS nano, 2021 - ACS Publications
DNA nanotechnology has produced a wide range of self-assembled structures, offering
unmatched possibilities in terms of structural design. Because of their programmable …

Designer DNA nanostructures for therapeutics

S Jiang, Z Ge, S Mou, H Yan, C Fan - Chem, 2021 - cell.com
The field of structural DNA nanotechnology applies the programmability of Watson-Crick
base pairing to the construction of custom nanostructures that are prescribed by the …