Variants in the FADS gene cluster modify the activity of polyunsaturated fatty acid (PUFA)
desaturation and the lipid composition in human blood and tissue. FADS variants have been …

Converging evidence implicates redox dysregulation as a pathological mechanism driving
the emergence of psychosis. Increased oxidative damage and decreased capacity of …

Anhedonia and amotivation are debilitating symptoms and represent unmet therapeutic
needs in a range of clinical conditions. The gut-microbiome-endocannabinoid axis might …

Our previous study showed that metabolic abnormalities reduced the levels of brain-derived
neurotrophic factor (BDNF) and deteriorated cognitive performance in patients with …

In the central nervous system omega-3 fatty acids modulate cell signaling and affect
dopaminergic and serotonergic pathways. On this basis, a new application for omega-3 fatty …

Background: Several monotherapy and augmentation strategies have been introduced to
improve the treatment of schizophrenia. The benefits of omega-3 polyunsaturated fatty acids …

Background Schizophrenia is a serious long-term psychotic disorder marked by positive and
negative symptoms, severe behavioral problems and cognitive function deficits. The cause …

Abstract Purpose of Review This review highlights recent advances in the prediction and
treatment of psychotic conversion. Over the past 25 years, research into the prodromal …

There is increasing awareness of the importance of polyunsaturated fatty acids (PUFAs) for
optimal brain development and function. In recent decades, researchers have confirmed the …

Background: The clinical high risk for psychosis (CHR-P) construct represents an
opportunity for prevention and early intervention in young adults, but the relationship …