Pyrazole has been recognized as a pharmacologically important privileged scaffold whose
derivatives produce almost all types of pharmacological activities and have attracted much …

Simple Summary Cyclin-dependent kinases (CDKs) are rich and viable therapeutic targets
for various cancers. The emergence of event-driven pharmacology as an alternative to …

Abstract Development of selective kinase inhibitors that target the ATP binding site
continues to be a challenge largely due to similar binding pockets. Palbociclib is a cyclin …

Abstract Cyclin-dependent kinase 9 (CDK9) is a member of the cyclin-dependent kinase
(CDK) family which is involved in transcriptional regulation of several genes, including the …

Cancer is one of the major leading causes of death worldwide despite many breakthroughs
in the development of novel anticancer drugs. The heterodimer CDK-Cyclin complex plays …

Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …

Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction.
Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions …

The transformation of a normal cell into a tumor cell is one of the initial steps in cell cycle
deregulation. The cell cycle is regulated by cyclin-dependent kinases (CDKs) that belong to …

Endometrial cancer (EC) is one of the most common malignant diseases worldwide.
Although many studies have been performed on EC, a systems analysis between …

Current antileishmanial treatment is hampered by limitations, such as drug toxicity and the
risk of treatment failure, which may be related to parasitic drug resistance. Given the urgent …