A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic …
Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …
are emerging as treatment options. This study sought to identify the most prevalent …
[HTML][HTML] DNA binding partners of YAP/TAZ
MK Kim, JW Jang, SC Bae - BMB reports, 2018 - ncbi.nlm.nih.gov
Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and
tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ …
tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ …
Integrative single-cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer
Cancer progression is driven by both somatic copy number aberrations (CNAs) and
chromatin remodeling, yet little is known about the interplay between these two classes of …
chromatin remodeling, yet little is known about the interplay between these two classes of …
Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis
Loss of WW domain-containing oxidoreductase (Wwox) expression has been observed in
breast cancer (BC). However, its regulatory effects are largely unknown, especially in triple …
breast cancer (BC). However, its regulatory effects are largely unknown, especially in triple …
Targeted deletion of Wwox reveals a tumor suppressor function
RI Aqeilan, F Trapasso, S Hussain… - Proceedings of the …, 2007 - National Acad Sciences
The WW domain-containing oxidoreductase (WWOX) spans the second most common
fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in …
fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in …
Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox
NP Mahajan, YE Whang, JL Mohler, HS Earp - Cancer research, 2005 - AACR
Aberrant activation of tyrosine kinases is linked causally to human cancers. Activated Cdc42-
associated kinase (Ack1), an intracellular tyrosine kinase, has primarily been studied for its …
associated kinase (Ack1), an intracellular tyrosine kinase, has primarily been studied for its …
WW domain–containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function
The WW domain–containing oxidoreductase, WWOX, is a tumor suppressor that is deleted
or altered in several cancer types. We recently showed that WWOX interacts with p73 and …
or altered in several cancer types. We recently showed that WWOX interacts with p73 and …
Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2γ transcription factor
RI Aqeilan, A Palamarchuk, RJ Weigel, JJ Herrero… - Cancer research, 2004 - AACR
The WWOX gene encodes a tumor suppressor WW domain-containing protein, Wwox.
Alterations of WWOX have been demonstrated in multiple types of cancer, and introduction …
Alterations of WWOX have been demonstrated in multiple types of cancer, and introduction …
WWOX: its genomics, partners, and functions
S Del Mare, Z Salah, RI Aqeilan - Journal of cellular …, 2009 - Wiley Online Library
The WW domain‐containing oxidoreductase (WWOX) spans one of the most active common
fragile sites (CFSs) involved in cancer, FRA16D. WWOX encodes a 46‐kDa protein that …
fragile sites (CFSs) involved in cancer, FRA16D. WWOX encodes a 46‐kDa protein that …
Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple …
We performed fluorescent in situ hybridization (FISH) for 16q23 abnormalities in 861
patients with newly diagnosed multiple myeloma and identified deletion of 16q [del (16q)] in …
patients with newly diagnosed multiple myeloma and identified deletion of 16q [del (16q)] in …