Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Lissencephaly ('smooth brain') is a severe brain disease associated with numerous
symptoms, including cognitive impairment, and shortened lifespan. The main causative …

The lissencephaly protein Lis1 has been reported to regulate the mechanical behavior of
cytoplasmic dynein, the primary minus-end-directed microtubule motor. However, the …

Cytoplasmic dynein-1 is a molecular motor that drives nearly all minus-end-directed
microtubule-based transport in human cells, performing functions that range from retrograde …

Cytoplasmic dynein is a two-headed microtubule-based motor responsible for diverse
intracellular movements, including minus-end-directed transport of organelles,,. The motility …

The molecular motor cytoplasmic dynein is responsible for most minus-end–directed,
microtubule-based transport in eukaryotic cells. It is especially important in neurons, where …

The organization and function of eukaryotic cells rely on the action of many different
molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of …

Cytoplasmic dynein drives the motility and force generation functions towards the
microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an …

Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions,
including cell division, intracellular transport, and brain development. The dynein regulator …

Dynein is the primary minus-end-directed microtubule motor protein. To achieve activation,
dynein binds to the dynactin complex and an adaptor to form the" activated dynein complex." …