[HTML][HTML] Aging and age‐related diseases: from mechanisms to therapeutic strategies

Z Li, Z Zhang, Y Ren, Y Wang, J Fang, H Yue, S Ma… - Biogerontology, 2021 - Springer
Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

[HTML][HTML] Physiological hormesis and hormetins in biogerontology

SIS Rattan - Current Opinion in Toxicology, 2022 - Elsevier
Research on the biology of aging and possibilities of interventions has gained a significant
push forward by incorporating the concept of mild stress-induced physiological hormesis …

Comparative dynamics of individual ageing among the investigative type of professionals living in Russia and Russian migrants to the EU countries

TN Berezina, NN Rybtsova, SA Rybtsov - European Journal of …, 2020 - mdpi.com
The goal of this study was to uncover the influence of professional activity, migration, and
gender on dynamics of subjective age and ageing biomarkers. We examined the …

Can blood-circulating factors unveil and delay your biological aging?

N Rybtsova, T Berezina, A Kagansky, S Rybtsov - Biomedicines, 2020 - mdpi.com
According to the World Health Organization, the population of over 60 will double in the next
30 years in the developed countries, which will enforce a further raise of the retirement age …

Aging, senescence and mitochondria: the PGC-1/ERR axis

M Vernier, V Giguère - Journal of Molecular Endocrinology, 2021 - jme.bioscientifica.com
Aging is a degenerative process that results from the accumulation of cellular and tissue
lesions, leading progressively to organ dysfunction and death. Although the biological basis …

[HTML][HTML] The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy

VB Pillai, S Samant, S Hund, M Gupta… - Aging (Albany NY …, 2021 - ncbi.nlm.nih.gov
Sirtuins have been shown to regulate the aging process. We have previously demonstrated
that Sirt6 blocks the pressure overload-induced cardiac hypertrophy in mice. Here, we show …

Modulation of mitochondrial function as a therapeutic strategy for neurodegenerative diseases

E Trushina, TKO Nguyen, S Trushin - The journal of prevention of …, 2023 - Springer
Despite recent FDA approval of anti-amyloid antibodies for Alzheimer's Disease, strategies
that target early molecular mechanisms and could delay or change the disease trajectory …

[HTML][HTML] The biological mechanism and emerging therapeutic interventions of liver aging

W Wang, K Xu, M Shang, X Li, X Tong… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Research on liver aging has become prominent and has attracted considerable interest in
uncovering the mechanism and therapeutic targets of aging to expand lifespan. In addition …

Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks

K Yusri, S Kumar, S Fong, J Gruber… - International Journal of …, 2024 - mdpi.com
Aging is a complex and time-dependent decline in physiological function that affects most
organisms, leading to increased risk of age-related diseases. Investigating the molecular …

The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies

A Kassab, N Rizk, S Prakash - International Journal of Molecular Sciences, 2022 - mdpi.com
Advances in aging studies brought about by heterochronic parabiosis suggest that aging
might be a reversable process that is affected by changes in the systemic milieu of organs …