Imaging and quantifying drug delivery in skin–Part 2: Fluorescence andvibrational spectroscopic imaging methods

AM Pena, X Chen, IJ Pence, T Bornschlögl… - Advanced drug delivery …, 2020 - Elsevier
Understanding the delivery and diffusion of topically-applied drugs on human skin is of
paramount importance in both pharmaceutical and cosmetics research. This information is …

Skin imaging using ultrasound imaging, optical coherence tomography, confocal microscopy, and two-photon microscopy in cutaneous oncology

BH Oh, KH Kim, KY Chung - Frontiers in medicine, 2019 - frontiersin.org
With the recognition of dermoscopy as a new medical technology and its available fee
assessment in Korea comes an increased interest in imaging-based dermatological …

[HTML][HTML] Multimodal analyses of vitiligo skin idenitfy tissue characteristics of stable disease

J Shiu, L Zhang, G Lentsch, JL Flesher, S Jin… - JCI insight, 2022 - ncbi.nlm.nih.gov
Vitiligo is an autoimmune skin disease characterized by the destruction of melanocytes by
autoreactive CD8+ T cells. Melanocyte destruction in active vitiligo is mediated by CD8+ T …

In vivo multiphoton microscopy detects longitudinal metabolic changes associated with delayed skin wound healing

JD Jones, HE Ramser, AE Woessner… - Communications …, 2018 - nature.com
Chronic wounds are difficult to diagnose and characterize due to a lack of quantitative
biomarkers. Label-free multiphoton microscopy has emerged as a useful imaging modality …

Artificial intelligence in multiphoton tomography: atopic dermatitis diagnosis

P Guimarães, A Batista, M Zieger, M Kaatz, K Koenig - Scientific reports, 2020 - nature.com
The diagnostic possibilities of multiphoton tomography (MPT) in dermatology have already
been demonstrated. Nevertheless, the analysis of MPT data is still time-consuming and …

In vivo multiphoton tomography and fluorescence lifetime imaging of human brain tumor tissue

SR Kantelhardt, D Kalasauskas, K König, E Kim… - Journal of neuro …, 2016 - Springer
High resolution multiphoton tomography and fluorescence lifetime imaging differentiates
glioma from adjacent brain in native tissue samples ex vivo. Presently, multiphoton …

Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis

D Pouli, M Balu, CA Alonzo, Z Liu, KP Quinn… - Science translational …, 2016 - science.org
Active changes in mitochondrial structure and organization facilitate cellular homeostasis.
Because aberrant mitochondrial dynamics are implicated in a variety of human diseases …

Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK …

J Lee, J Benavides, R Manwar… - Skin Research and …, 2023 - Wiley Online Library
Background Phacomatosis pigmentokeratotica (PPK) is a distinct and rare type of epidermal
nevus syndrome characterized by coexisting nonepidermolytic organoid sebaceous nevus …

[HTML][HTML] Research techniques made simple: emerging imaging technologies for noninvasive optical biopsy of human skin

G Lentsch, EG Baugh, B Lee, M Aszterbaum… - Journal of Investigative …, 2022 - Elsevier
Over the past few years, high-resolution optical imaging technologies such as optical
coherence tomography (OCT), reflectance confocal microscopy (RCM), and multiphoton …

Automated quantification of three-dimensional organization of fiber-like structures in biological tissues

Z Liu, D Pouli, D Sood, A Sundarakrishnan… - Biomaterials, 2017 - Elsevier
Fiber-like structures are prevalent in biological tissues, yet quantitative approaches to
assess their three-dimensional (3D) organization are lacking. We develop 3D directional …