[HTML][HTML] Engineering interferons and interleukins for cancer immunotherapy
Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …
various stimuli and act locally to regulate many aspects of human physiology and disease …
The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy
X Zheng, Y Wu, J Bi, Y Huang, Y Cheng, Y Li… - Cellular & molecular …, 2022 - nature.com
Cytokines exert powerful immunomodulatory effects that are critical to physiology and
pathology in humans. The application of natural cytokines in clinical studies has not been …
pathology in humans. The application of natural cytokines in clinical studies has not been …
[HTML][HTML] A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
A Quijano-Rubio, AM Bhuiyan, H Yang, I Leung… - Nature …, 2023 - nature.com
The therapeutic potential of recombinant cytokines has been limited by the severe side
effects of systemic administration. We describe a strategy to reduce the dose-limiting …
effects of systemic administration. We describe a strategy to reduce the dose-limiting …
Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …
[HTML][HTML] Fundamentals of T cell metabolism and strategies to enhance cancer immunotherapy
GO Rangel Rivera, HM Knochelmann… - Frontiers in …, 2021 - frontiersin.org
Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated
immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing …
immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing …
The present and future of bispecific antibodies for cancer therapy
Bispecific antibodies (bsAbs) enable novel mechanisms of action and/or therapeutic
applications that cannot be achieved using conventional IgG-based antibodies …
applications that cannot be achieved using conventional IgG-based antibodies …
Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy
K Mortezaee, J Majidpoor - Cellular Oncology, 2022 - Springer
Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …
They provide a bridge between innate and adaptive immunity through releasing cytokines …
[HTML][HTML] (Im) maturity in tumor ecosystem
K Mortezaee, J Majidpoor - Frontiers in oncology, 2022 - frontiersin.org
Tumors have special features that distinct them from their normal counterparts. Immature
cells in a tumor mass and their critical contributions to the tumorigenesis will open new …
cells in a tumor mass and their critical contributions to the tumorigenesis will open new …
Checkpoint inhibitor/interleukin‐based combination therapy of cancer
K Mortezaee, J Majidpoor - Cancer medicine, 2022 - Wiley Online Library
Background Immunotherapy using immune checkpoint inhibitors (ICIs) is the current focus in
cancer immunotherapy. However, issues are raised in the area, as the recent studies …
cancer immunotherapy. However, issues are raised in the area, as the recent studies …
An engineered IL15 cytokine mutein fused to an anti-PD1 improves intratumoral T-cell function and antitumor immunity
The use of cytokines for immunotherapy shows clinical efficacy but is frequently
accompanied by severe adverse events caused by excessive and systemic immune …
accompanied by severe adverse events caused by excessive and systemic immune …