Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Astrocytes have many roles within the brain parenchyma, and a subpopulation restricted to
germinal niches functions as neural stem cells (NSCs) that produce various types of …

Abstract Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an
important role in axon guidance,,,,. Previous studies have demonstrated that Sema3a …

Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

Astrocytes, the most abundant cells in the central nervous system, promote synapse
formation and help to refine neural connectivity. Although they are allocated to spatially …

The membrane protein Nogo-A was initially characterized as a CNS-specific inhibitor of
axonal regeneration. Recent studies have uncovered regulatory roles of Nogo proteins and …

Amyotrophic lateral sclerosis (ALS) is a lethal disease, characterized by progressive death
of motor neurons with unknown etiology. Evidence from animal models indicates that …

Many neurological disorders are characterised by structural changes in neuronal
connections, ranging from presymptomatic synaptic changes to the loss or rewiring of entire …

Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-
based proteomics. However, antigenic targets of disease are unknown for over 10% of …