HMGA genes and proteins in development and evolution

R Vignali, S Marracci - International journal of molecular sciences, 2020 - mdpi.com
HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …

EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma

A Jenseit, A Camgöz, SM Pfister, M Kool - Acta neuropathologica, 2022 - Springer
Ependymomas (EPN) are tumors of the central nervous system (CNS) that can arise in the
supratentorial brain (ST-EPN), hindbrain or posterior fossa (PF-EPN) or anywhere in the …

Setd1a insufficiency in mice attenuates excitatory synaptic function and recapitulates schizophrenia-related behavioral abnormalities

K Nagahama, K Sakoori, T Watanabe, Y Kishi… - Cell reports, 2020 - cell.com
SETD1A encodes a histone methyltransferase whose de novo mutations are identified in
schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate …

HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation

N Kuwayama, T Kujirai, Y Kishi, R Hirano… - Nature …, 2023 - nature.com
Identification of factors that regulate chromatin condensation is important for understanding
of gene regulation. High-mobility group AT-hook (HMGA) proteins 1 and 2 are abundant …

Perturbations of the proteome and of secreted metabolites in primary astrocytes from the hSOD1 (G93A) ALS mouse model

R Stella, RS Bonadio, S Cagnin, ML Massimino… - International Journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose
pathophysiology is largely unknown. Despite the fact that motor neuron (MN) death is …

BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors

H Omiya, S Yamaguchi, T Watanabe, T Kuniya… - Scientific Reports, 2021 - nature.com
The lateral ventricles of the adult mammalian brain are lined by a single layer of multiciliated
ependymal cells, which generate a flow of cerebrospinal fluid through directional beating of …

Recent advances in smooth muscle tumors with PGR and PLAG1 gene fusions and myofibroblastic uterine neoplasms

S Chiang - Genes, Chromosomes and Cancer, 2021 - Wiley Online Library
Uterine epithelioid and myxoid leiomyosarcomas and inflammatory myofibroblastic tumors
are rare mesenchymal neoplasms. Next‐generation sequencing recently detected novel …

Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development

T Nakagawa, Y Wada, S Katada, Y Kishi - Glia, 2020 - Wiley Online Library
The nervous system consists of several hundred neuronal subtypes and glial cells that show
specific gene expression and are generated from common ancestors, neural stem cells …

Goat Pleomorphic Adenoma Gene 1 (PLAG1): mRNA Expression, CNV Detection and Associations with Growth Traits

Q Wang, Z Wei, H Zhu, C Pan, Z Akhatayeva, X Song… - Animals, 2023 - mdpi.com
Simple Summary The pleomorphic adenoma gene 1 (PLAG1) gene has attracted a lot of
attention as a gene related to myogenesis. The PLAG1 gene is a key gene for growth traits …

The Role of PLAG1 in Mouse Brain Development and Neurogenesis

JG Gasperoni, SC Tran, SVH Grommen… - Molecular …, 2024 - Springer
The pleomorphic adenoma gene 1 (Plag1) is a transcription factor involved in the regulation
of growth and cellular proliferation. Here, we report the spatial distribution and functional …