The diagnosis of benign and malignant soft tissue and bone neoplasms is a challenging
area of surgical pathology, due to the large number, rarity, and histologic diversity of tumor …

The mediastinal compartment harbours vital organs and structures, including the heart, great
vessels, major airways, and thymus. These structures are embedded in and associated with …

Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma,
occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and …

Diagnosing bone and soft tissue neoplasms remains challenging because of the large
number of subtypes, many of which lack diagnostic biomarkers. DNA methylation profiles …

Background Central conventional chondrosarcoma (CS) is the most common subtype of
primary malignant bone tumour in adults. Treatment options are usually limited to surgery …

Simple Summary Measurements of circulating tumor DNA is a promising new tool in early
detection of cancer and the detection of residual cancer disease. To ensure a high test …

Context.—Immunohistochemistry plays an important role in dermatopathology, particularly
for melanocytic lesions and poorly differentiated malignancies. In the field of bone and soft …

DICER1 syndrome is characterized by a unique combination of features and a growing list of
associated rare tumors. Traditionally, gonadal or extra-gonadal teratomas have not been …

Soft tissue sarcomas comprise a heterogeneous group of neoplasms. Although soft tissue
malignancies make up only 2% of adult cancers, classification based on histomorphology …

Bone marrow mesenchymal stem cells (BMSCs) have strong regenerative potential and
show good application prospects for treating clinical diseases. However, in the process of …