Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is
phosphorylated to form sphingosine-1-phosphate (S1P). Ceramide, SPH, and S1P are …

Long non-coding RNAs (ncRNAs) have been shown to regulate important biological
processes that support normal cellular functions. Aberrant regulation of these essential …

STAG2, a cohesin family gene, is among the most recurrently mutated genes in cancer.
STAG2 loss of function (LOF) is associated with aggressive behavior in Ewing sarcoma, a …

Background Discovery that the transcriptional output of the human genome is far more
complex than predicted by the current set of protein-coding annotations and that most RNAs …

The CCCTC-binding factor (CTCF), which anchors DNA loops that organize the genome into
structural domains, has a central role in gene control by facilitating or constraining …

Fenretinide, a synthetic retinoid, has emerged as a promising anticancer agent based on
numerous in vitro and animal studies, as well as chemoprevention clinical trials. In vitro …

Hypoxia develops during the growth of solid tumors and influences tumoral activity in
multiple ways. Low oxygen tension is also present in the bone microenvironment where …

Aminoferrocene-based prodrugs are activated under cancer-specific conditions (high
concentration of reactive oxygen species, ROS) with the formation of glutathione scavengers …

Purpose To determine the maximal tolerated dosage (MTD) of oral fenretinide given as
intact capsules for 7 days, repeated every 21 days, in children with high-risk solid tumors …

Anti-tumor activity of bakuchiol, an analogue of resveratrol, was investigated on human lung
adenocarcinoma A549 cell line. MTT assay revealed that IC50 of bakuchiol at 72h was …