Considerable efforts have been made since the 1950s to better understand the cellular and
molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now …

Metformin is the most widely prescribed drug to treat patients with type II diabetes, for whom
retrospective studies suggest that metformin may have anticancer properties. However, in …

The senescence programme is implicated in diverse biological processes, including
embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo …

Nephrotoxicity is one of the most important side effects and therapeutical limitations of
aminoglycoside antibiotics, especially gentamicin. Despite rigorous patient monitoring …

Due to high relative blood flow the kidney is prone to drug-induced damage.
Aminoglycoside type antibiotic gentamicin is one of the leading cause of drug-induced …

Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes mellitus
(T2DM), acting via indirect activation of 5′ Adenosine monophosphate-activated Protein …

As human life expectancy keeps increasing, ageing populations present a growing
challenge for clinical practices. Human ageing is associated with molecular, structural, and …

Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of
poor prognosis in human breast cancer patients, and is associated with early tumor …

Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …

The animal models are pivotal for understanding the characteristics of acute renal failure
(ARF) and development of effective therapy for its optimal management. Since the etiology …