Staphylococcus aureus host interactions and adaptation
BP Howden, SG Giulieri, T Wong Fok Lung… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …
Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19
CI van der Made, MG Netea, FL van der Veerdonk… - Genome medicine, 2022 - Springer
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …
have been gained into virus biology and the host factors that modulate the human immune …
From second thoughts on the germ theory to a full-blown host theory
JL Casanova - Proceedings of the National Academy of …, 2023 - National Acad Sciences
In 1955, René Dubos famously expressed his “second thoughts on the germ theory”,
attributing infectious diseases to various “changing circumstances” that weaken the host by …
attributing infectious diseases to various “changing circumstances” that weaken the host by …
How to build a fire: the genetics of autoinflammatory diseases
J Zhang, PY Lee, I Aksentijevich… - Annual Review of …, 2023 - annualreviews.org
Systemic autoinflammatory diseases (SAIDs) are a heterogeneous group of disorders
caused by excess activation of the innate immune system in an antigen-independent …
caused by excess activation of the innate immune system in an antigen-independent …
[HTML][HTML] A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome
OTULIN-related autoinflammatory syndrome (ORAS), a severe autoinflammatory disease, is
caused by biallelic pathogenic variants of OTULIN, a linear ubiquitin-specific …
caused by biallelic pathogenic variants of OTULIN, a linear ubiquitin-specific …
Human determinants of age-dependent patterns of death from infection
L Abel, JL Casanova - Immunity, 2024 - cell.com
Regardless of microbial virulence (ie, the global infection-fatality ratio), age generally drives
the prevalence of death from infection in unvaccinated humans. Four mortality patterns are …
the prevalence of death from infection in unvaccinated humans. Four mortality patterns are …
Computational methods for single-cell proteomics
SM Guldberg, TLH Okholm… - Annual review of …, 2023 - annualreviews.org
Advances in single-cell proteomics technologies have resulted in high-dimensional datasets
comprising millions of cells that are capable of answering key questions about biology and …
comprising millions of cells that are capable of answering key questions about biology and …
[HTML][HTML] Natural photothermal-responsive MXene-based antimicrobial nanomaterials Ti3C2/Au NPs for the treatment of deep Staphylococcus aureus-Infected wound
X Chen, J Wang, Y Endo, G Liu, N Wang, Z Shao - Materials & Design, 2023 - Elsevier
Background Infection by pathogenic bacteria presents a serious public health issue due to
high morbidity and death rates. To aid infective wound closure and healing, a variety of anti …
high morbidity and death rates. To aid infective wound closure and healing, a variety of anti …
Dominant negative OTULIN related autoinflammatory syndrome
S Davidson, Y Shibata, S Collard, P Laohamonthonku… - medRxiv, 2023 - medrxiv.org
Biallelic loss of function mutations in the linear chain specific deubiquitinase (DUB) OTULIN
(OTU Deubiquitinase With Linear Linkage Specificity) result in OTULIN Related …
(OTU Deubiquitinase With Linear Linkage Specificity) result in OTULIN Related …
[HTML][HTML] Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency
Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but
not abolished, cellular responses to IFN-α/β (underlying viral diseases in the patients) and to …
not abolished, cellular responses to IFN-α/β (underlying viral diseases in the patients) and to …