Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …

In 1955, René Dubos famously expressed his “second thoughts on the germ theory”,
attributing infectious diseases to various “changing circumstances” that weaken the host by …

Systemic autoinflammatory diseases (SAIDs) are a heterogeneous group of disorders
caused by excess activation of the innate immune system in an antigen-independent …

OTULIN-related autoinflammatory syndrome (ORAS), a severe autoinflammatory disease, is
caused by biallelic pathogenic variants of OTULIN, a linear ubiquitin-specific …

Regardless of microbial virulence (ie, the global infection-fatality ratio), age generally drives
the prevalence of death from infection in unvaccinated humans. Four mortality patterns are …

Advances in single-cell proteomics technologies have resulted in high-dimensional datasets
comprising millions of cells that are capable of answering key questions about biology and …

Background Infection by pathogenic bacteria presents a serious public health issue due to
high morbidity and death rates. To aid infective wound closure and healing, a variety of anti …

Biallelic loss of function mutations in the linear chain specific deubiquitinase (DUB) OTULIN
(OTU Deubiquitinase With Linear Linkage Specificity) result in OTULIN Related …

Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but
not abolished, cellular responses to IFN-α/β (underlying viral diseases in the patients) and to …