The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …

Nearly 100 proteins are known to be regulated by hsp90. Most of these substrates or “client
proteins” are involved in signal transduction, and they are brought into complex with hsp90 …

Hepadnaviruses, including human hepatitis B virus (HBV), replicate through reverse
transcription of an RNA intermediate, the pregenomic RNA (pgRNA). Despite this kinship to …

Hepatitis B virus (HBV), the causative agent of B-type hepatitis in humans, is the type
member of the Hepadnaviridae, hepatotropic DNA viruses that replicate via reverse …

Viruses are intracellular pathogens responsible for a vast number of human diseases. Due
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …

Chronic hepatitis B virus (HBV) infection, a serious public health problem leading to cirrhosis
and hepatocellular carcinoma, is currently treated with either pegylated alpha interferon …

Hallmarks of the hepadnavirus replication cycle are the formation of covalently closed
circular DNA (cccDNA) and the reverse transcription of a pregenomic RNA (pgRNA) in core …

Molecular chaperones facilitate the correct folding of other proteins under physiological and
stress conditions. Recently it has become evident that various co‐chaperone proteins …

Virus proliferation depends on the successful recruitment of host cellular components for
their own replication, protein synthesis, and virion assembly. In the course of virus particle …

The highly coordinated interactions of several molecular chaperones, including hsp70 and
hsp90, are required for the folding and conformational regulation of a variety of proteins in …