The term ferroptosis was put forward in 2012 and has been researched exponentially over
the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed …

As the primary barrier between an organism and its environment, epithelial cells are well-
positioned to regulate tolerance while preserving immunity against pathogens. Class II …

Background The gut microbiome plays an important role in human health and disease.
Gnotobiotic animal and in vitro cell-based models provide some informative insights into …

Since the 1970s, the role of infectious diseases in the pathogenesis of Graves' disease (GD)
has been an object of intensive research. The last decade has witnessed many studies on …

Clinical manifestations and response to therapies in ulcerative colitis (UC) are
heterogeneous, yet patient classification criteria for tailored therapies are currently lacking …

Inflammatory bowel disease affects more than 2 million people in Europe, with almost 20%
of patients being diagnosed in pediatric age. Patients with inflammatory bowel disease are …

Angiogenesis is an important component of pathogenesis of inflammatory bowel disease
(IBD). Chronic inflammation and angiogenesis are two closely related processes. Chronic …

Lactic acid bacteria inhibits NFκB-mediated transcriptional activation of IBD causing factors
(IL-23/IL-17/CD40) by reducing histone acetylation while enhancing DNA methylation. The …

Inflammatory bowel diseases (IBD) are characterized by wasting and chronic intestinal
inflammation triggered by various cytokine-mediated pathways. In recent years, it was …

Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health.
However, there is no existing system for a long-term co-culture of human innate immune …