Fluorescent labeling of biomolecules with organic probes

MST Gonçalves - Chemical reviews, 2009 - ACS Publications
Many areas of modern technology are dependent on sensitive analytical techniques, and
this is particularly true for environmental science, medicine, pharmacy, and cellular biology …

Redox-based regulation of signal transduction: principles, pitfalls, and promises

YMW Janssen-Heininger, BT Mossman… - Free Radical Biology …, 2008 - Elsevier
Oxidants are produced as a by-product of aerobic metabolism, and organisms ranging from
prokaryotes to mammals have evolved with an elaborate and redundant complement of …

Reducing acetylated tau is neuroprotective in brain injury

MK Shin, E Vázquez-Rosa, Y Koh, M Dhar, K Chaubey… - Cell, 2021 - cell.com
Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for
Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites …

AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation

C Chang, H Su, D Zhang, Y Wang, Q Shen, B Liu… - Molecular cell, 2015 - cell.com
Eukaryotes initiate autophagy to cope with the lack of external nutrients, which requires the
activation of the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase Sirtuin 1 …

Bioenergetics and the formation of mitochondrial reactive oxygen species

V Adam-Vizi, C Chinopoulos - Trends in pharmacological sciences, 2006 - cell.com
The contribution of mitochondria to the manifestation of disease is ascribed largely to the
production of reactive oxygen species (ROS), which are obligatory by-products of …

Inflammation and lung cancer: roles of reactive oxygen/nitrogen species

N Azad, Y Rojanasakul, V Vallyathan - Journal of Toxicology and …, 2008 - Taylor & Francis
The lung is a highly specialized organ that facilitates uptake of oxygen and release of
carbon dioxide. Due to its unique structure providing enormous surface area to outside …

[HTML][HTML] Critical protein GAPDH and its regulatory mechanisms in cancer cells

JY Zhang, F Zhang, CQ Hong, AE Giuliano… - Cancer biology & …, 2015 - ncbi.nlm.nih.gov
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), initially identified as a
glycolytic enzyme and considered as a housekeeping gene, is widely used as an internal …

On the functional diversity of glyceraldehyde-3-phosphate dehydrogenase: biochemical mechanisms and regulatory control

MA Sirover - Biochimica et Biophysica Acta (BBA)-General Subjects, 2011 - Elsevier
Background New studies provide evidence that glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is not simply a classical glycolytic protein of little interest. Instead …

GAPDH: a common enzyme with uncommon functions

C Nicholls, H Li, JP Liu - Clinical and Experimental …, 2012 - Wiley Online Library
Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) has long been recognized as an
important enzyme for energy metabolism and the production of ATP and pyruvate through …

Novel roles for GAPDH in cell death and carcinogenesis

A Colell, DR Green, JE Ricci - Cell Death & Differentiation, 2009 - nature.com
Growing evidence points to the fact that glucose metabolism has a central role in
carcinogenesis. Among the enzymes controlling this energy production pathway …