Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

Melatonin, mostly released by the pineal gland, is a circadian rhythm-regulated and
multifunctional hormone. Great advances in melatonin research have been made, including …

The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

Background Oxidative stress, defined as an imbalance between pro-oxidants and
neutralizing antioxidants within the body, is a growing public health concern. Oxidative …

Last year melatonin was 60 years old, or at least its discovery was 60 years ago. The
molecule itself may well be almost as old as life itself. So it is time to take yet another …

Simple Summary In mammals, circadian rhythms in nearly all behaviors and physiological
processes are controlled by the suprachiasmatic nucleus, a collection of neurons in the …

Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in
vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms …

Abstract Circadian (24-h) clocks are cell-autonomous biological oscillators that orchestrate
many aspects of our physiology on a daily basis. Numerous circadian rhythms in …

Synchronization of mammalian breeding activity to the annual change of photoperiod and
environmental conditions is of the utmost importance for individual survival and species …

This contribution reviews the role of inbred and transgenic mouse strains for deciphering the
mammalian melatoninergic and circadian system. It focusses on the pineal organ as …