Deuterium‐and tritium‐labelled compounds: applications in the life sciences
J Atzrodt, V Derdau, WJ Kerr… - Angewandte chemie …, 2018 - Wiley Online Library
Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …
Plant phenotyping: from bean weighing to image analysis
Plant phenotyping refers to a quantitative description of the plant's anatomical,
ontogenetical, physiological and biochemical properties. Today, rapid developments are …
ontogenetical, physiological and biochemical properties. Today, rapid developments are …
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the
mechanism that balances OXPHOS activity and intracellular oxygen availability remains …
mechanism that balances OXPHOS activity and intracellular oxygen availability remains …
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ
Q Zhou, WW Sun, JC Chen, HL Zhang, J Liu… - Nature …, 2022 - nature.com
Whether amino acids act on cellular insulin signaling remains unclear, given that increased
circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here …
circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here …
Stable isotope labelling methods in mass spectrometry-based quantitative proteomics
O Chahrour, D Cobice, J Malone - Journal of pharmaceutical and …, 2015 - Elsevier
Mass-spectrometry based proteomics has evolved as a promising technology over the last
decade and is undergoing a dramatic development in a number of different areas, such as; …
decade and is undergoing a dramatic development in a number of different areas, such as; …
Review, evaluation, and discussion of the challenges of missing value imputation for mass spectrometry-based label-free global proteomics
BJM Webb-Robertson, HK Wiberg… - Journal of proteome …, 2015 - ACS Publications
In this review, we apply selected imputation strategies to label-free liquid chromatography–
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …
Dealing with missing values in proteomics data
Proteomics data are often plagued with missingness issues. These missing values (MVs)
threaten the integrity of subsequent statistical analyses by reduction of statistical power …
threaten the integrity of subsequent statistical analyses by reduction of statistical power …
Emerging genomic tools for legume breeding: current status and future prospects
Legumes play a vital role in ensuring global nutritional food security and improving soil
quality through nitrogen fixation. Accelerated higher genetic gains is required to meet the …
quality through nitrogen fixation. Accelerated higher genetic gains is required to meet the …
Gel‐based and gel‐free quantitative proteomics approaches at a glance
C Abdallah, E Dumas-Gaudot, J Renaut… - … journal of plant …, 2012 - Wiley Online Library
Two‐dimensional gel electrophoresis (2‐DE) is widely applied and remains the method of
choice in proteomics; however, pervasive 2‐DE‐related concerns undermine its prospects …
choice in proteomics; however, pervasive 2‐DE‐related concerns undermine its prospects …
Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery
F Raimondo, L Morosi, C Chinello, F Magni… - …, 2011 - Wiley Online Library
Exosomes are membranous vesicles released by cells in extracellular fluids: they have been
found and analyzed in blood, urine, amniotic fluid, breast milk, seminal fluid, saliva and …
found and analyzed in blood, urine, amniotic fluid, breast milk, seminal fluid, saliva and …