Deuterium‐and tritium‐labelled compounds: applications in the life sciences

J Atzrodt, V Derdau, WJ Kerr… - Angewandte chemie …, 2018 - Wiley Online Library
Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

Plant phenotyping: from bean weighing to image analysis

A Walter, F Liebisch, A Hund - Plant methods, 2015 - Springer
Plant phenotyping refers to a quantitative description of the plant's anatomical,
ontogenetical, physiological and biochemical properties. Today, rapid developments are …

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

Y Mao, J Zhang, Q Zhou, X He, Z Zheng, Y Wei, K Zhou… - Cell Research, 2024 - nature.com
Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the
mechanism that balances OXPHOS activity and intracellular oxygen availability remains …

Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

Q Zhou, WW Sun, JC Chen, HL Zhang, J Liu… - Nature …, 2022 - nature.com
Whether amino acids act on cellular insulin signaling remains unclear, given that increased
circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here …

Stable isotope labelling methods in mass spectrometry-based quantitative proteomics

O Chahrour, D Cobice, J Malone - Journal of pharmaceutical and …, 2015 - Elsevier
Mass-spectrometry based proteomics has evolved as a promising technology over the last
decade and is undergoing a dramatic development in a number of different areas, such as; …

Review, evaluation, and discussion of the challenges of missing value imputation for mass spectrometry-based label-free global proteomics

BJM Webb-Robertson, HK Wiberg… - Journal of proteome …, 2015 - ACS Publications
In this review, we apply selected imputation strategies to label-free liquid chromatography–
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …

Dealing with missing values in proteomics data

W Kong, HWH Hui, H Peng, WWB Goh - Proteomics, 2022 - Wiley Online Library
Proteomics data are often plagued with missingness issues. These missing values (MVs)
threaten the integrity of subsequent statistical analyses by reduction of statistical power …

Emerging genomic tools for legume breeding: current status and future prospects

MK Pandey, M Roorkiwal, VK Singh… - Frontiers in Plant …, 2016 - frontiersin.org
Legumes play a vital role in ensuring global nutritional food security and improving soil
quality through nitrogen fixation. Accelerated higher genetic gains is required to meet the …

Gel‐based and gel‐free quantitative proteomics approaches at a glance

C Abdallah, E Dumas-Gaudot, J Renaut… - … journal of plant …, 2012 - Wiley Online Library
Two‐dimensional gel electrophoresis (2‐DE) is widely applied and remains the method of
choice in proteomics; however, pervasive 2‐DE‐related concerns undermine its prospects …

Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery

F Raimondo, L Morosi, C Chinello, F Magni… - …, 2011 - Wiley Online Library
Exosomes are membranous vesicles released by cells in extracellular fluids: they have been
found and analyzed in blood, urine, amniotic fluid, breast milk, seminal fluid, saliva and …