The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …

The role of the Notch signaling pathway in neural development has been well established
over many years. More recent studies, however, have demonstrated that Notch continues to …

Dopamine (DA) receptors play critical roles in a wide range of behaviours, including sensory
processing, motor function, reward and arousal. As such, aberrant DA signalling is …

A powerful feature of adaptive memory is its inherent flexibility. Alcohol and other addictive
substances can remold neural circuits important for memory to reduce this flexibility …

Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of
abuse create strong, inappropriate, and lasting memories that contribute to many of their …

The brain constantly compares past and present experiences to predict the future, thereby
enabling instantaneous and future behavioral adjustments. Integration of external …

Dysregulated motivation to consume psychoactive substances leads to addictive behaviors
that often result in serious health consequences. Understanding the neuronal mechanisms …

Methamphetamine (METH), a widely abused stimulant drug, induces psychosis in
approximately half of abusers; this effect is becoming a major concern for society. Although …