CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

Deoxyribonucleic acid (DNA) is a promising synthesizer for precisely constructing almost
arbitrary geometry in two and three dimensions. Among various DNA-based soft materials …

DNA hydrogels, which take advantage of the unique properties of functional DNA motifs,
such as specific molecular recognition, programmable and high‐precision assembly …

Rolling circle replication (RCR), including rolling circle amplification (RCA) and rolling circle
transcription (RCT), is an isothermal enzymatic reaction. Because of its high amplification …

RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …

Nanoparticle‐based small interfering RNA (siRNA) therapy shows great promise for
glioblastoma (GBM). However, charge associated toxicity and limited blood–brain‐barrier …

Cancer is one of the most complex diseases that has resulted in multiple genetic disorders
and cellular abnormalities. Globally, cancer is the most common health concern disease that …

The delivery of nucleic acids with transient activity for genetic engineering is a promising
methodology with potential applications in the treatment of diseases ranging from cancer …

Small interfering RNA (siRNA) holds inherent advantages and great potential for treating
refractory diseases. However, lack of suitable siRNA delivery systems that demonstrate …

Genetic diseases seriously threaten human health and have always been one of the
refractory conditions facing humanity. Currently, gene therapy drugs such as siRNA, shRNA …