RNA sequencing: new technologies and applications in cancer research
M Hong, S Tao, L Zhang, LT Diao, X Huang… - Journal of hematology & …, 2020 - Springer
Over the past few decades, RNA sequencing has significantly progressed, becoming a
paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing …
paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing …
The status of the human gene catalogue
Scientists have been trying to identify every gene in the human genome since the initial draft
was published in 2001. In the years since, much progress has been made in identifying …
was published in 2001. In the years since, much progress has been made in identifying …
Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty
C Badowski, B He, LX Garmire - NPJ precision oncology, 2022 - nature.com
Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …
Towards a complete map of the human long non-coding RNA transcriptome
B Uszczynska-Ratajczak, J Lagarde… - Nature Reviews …, 2018 - nature.com
Gene maps, or annotations, enable us to navigate the functional landscape of our genome.
They are a resource upon which virtually all studies depend, from single-gene to genome …
They are a resource upon which virtually all studies depend, from single-gene to genome …
GPNMB confers risk for Parkinson's disease through interaction with α-synuclein
Many risk loci for Parkinson's disease (PD) have been identified by genome-wide
association studies (GWASs), but target genes and mechanisms remain largely unknown …
association studies (GWASs), but target genes and mechanisms remain largely unknown …
RNA‐Seq methods for transcriptome analysis
R Hrdlickova, M Toloue, B Tian - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Deep sequencing has been revolutionizing biology and medicine in recent years, providing
single base‐level precision for our understanding of nucleic acid sequences in high …
single base‐level precision for our understanding of nucleic acid sequences in high …
[HTML][HTML] Translating RNA sequencing into clinical diagnostics: opportunities and challenges
SA Byron, KR Van Keuren-Jensen… - Nature Reviews …, 2016 - nature.com
With the emergence of RNA sequencing (RNA-seq) technologies, RNA-based biomolecules
hold expanded promise for their diagnostic, prognostic and therapeutic applicability in …
hold expanded promise for their diagnostic, prognostic and therapeutic applicability in …
Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)
RML Queiroz, T Smith, E Villanueva… - Nature …, 2019 - nature.com
Existing high-throughput methods to identify RNA-binding proteins (RBPs) are based on
capture of polyadenylated RNAs and cannot recover proteins that interact with …
capture of polyadenylated RNAs and cannot recover proteins that interact with …
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes
High-throughput single-cell RNA sequencing is a powerful technique but only generates
short reads from one end of a cDNA template, limiting the reconstruction of highly diverse …
short reads from one end of a cDNA template, limiting the reconstruction of highly diverse …
Discovery and annotation of long noncoding RNAs
JS Mattick, JL Rinn - Nature structural & molecular biology, 2015 - nature.com
Recent advances in RNA-sequencing technologies have led to the discovery of thousands
of previously unannotated noncoding transcripts, including many long noncoding RNAs …
of previously unannotated noncoding transcripts, including many long noncoding RNAs …